Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: other route
Remarks:
other: treatment for 4 days
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature - Patty, Industrial hygiene and toxicology

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
No information
Author:
Fassett DW, Irish DD (ed.)
Year:
1963
Bibliographic source:
Patty's Industrial Hygiene|and Toxicology, sec. ed. (1963)
Title:
No information
Author:
Biodynamics Inc. data, Project No. 98-3531, July 29 (1991)|(at the repuest of Synthetic Organic Chemical Manufacturers|Association)
Title:
No information
Author:
Research Triangle Institute, Project No. 60C-4652, August 10|(1992) (at the repuest of the Synthetic Organic Chemical|Manufacturers Association)

Materials and methods

Principles of method if other than guideline:
guinea pigs were treated ip with a dose of 1 cm³ daily of tributyl phosphate for 4 days
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl phosphate
EC Number:
204-800-2
EC Name:
Tributyl phosphate
Cas Number:
126-73-8
Molecular formula:
C12H27O4P
IUPAC Name:
tributyl phosphate
Details on test material:
no data

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
1 cc./kg bw/day
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

2/3 deaths

Applicant's summary and conclusion

Executive summary:

guinea pigs were treated ip with a dose of 1 cm³ daily of tributyl phosphate for 4 days. Two out of three animals died.