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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
repeated dose toxicity: other route
Remarks:
other: treatment for 4 days
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature - Patty, Industrial hygiene and toxicology

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
No information
Author:
Fassett DW, Irish DD (ed.)
Year:
1963
Bibliographic source:
Patty's Industrial Hygiene|and Toxicology, sec. ed. (1963)
Title:
No information
Author:
Biodynamics Inc. data, Project No. 98-3531, July 29 (1991)|(at the repuest of Synthetic Organic Chemical Manufacturers|Association)
Title:
No information
Author:
Research Triangle Institute, Project No. 60C-4652, August 10|(1992) (at the repuest of the Synthetic Organic Chemical|Manufacturers Association)

Materials and methods

Principles of method if other than guideline:
guinea pigs were treated ip with a dose of 1 cm³ daily of tributyl phosphate for 4 days
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl phosphate
EC Number:
204-800-2
EC Name:
Tributyl phosphate
Cas Number:
126-73-8
Molecular formula:
C12H27O4P
IUPAC Name:
tributyl phosphate
Details on test material:
no data

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
1 cc./kg bw/day
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

2/3 deaths

Applicant's summary and conclusion

Executive summary:

guinea pigs were treated ip with a dose of 1 cm³ daily of tributyl phosphate for 4 days. Two out of three animals died.