Registration Dossier
Registration Dossier
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EC number: 204-800-2 | CAS number: 126-73-8
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: treatment for 4 days
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature - Patty, Industrial hygiene and toxicology
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- No information
- Author:
- Fassett DW, Irish DD (ed.)
- Year:
- 1 963
- Bibliographic source:
- Patty's Industrial Hygiene|and Toxicology, sec. ed. (1963)
- Title:
- No information
- Author:
- Biodynamics Inc. data, Project No. 98-3531, July 29 (1991)|(at the repuest of Synthetic Organic Chemical Manufacturers|Association)
- Title:
- No information
- Author:
- Research Triangle Institute, Project No. 60C-4652, August 10|(1992) (at the repuest of the Synthetic Organic Chemical|Manufacturers Association)
Materials and methods
- Principles of method if other than guideline:
- guinea pigs were treated ip with a dose of 1 cm³ daily of tributyl phosphate for 4 days
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tributyl phosphate
- EC Number:
- 204-800-2
- EC Name:
- Tributyl phosphate
- Cas Number:
- 126-73-8
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- tributyl phosphate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 cc./kg bw/day
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
2/3 deaths
Applicant's summary and conclusion
- Executive summary:
guinea pigs were treated ip with a dose of 1 cm³ daily of tributyl phosphate for 4 days. Two out of three animals died.
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