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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient data documentation
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1936

Materials and methods

Principles of method if other than guideline:
intraperitoneal application: one rabbit each received a single injection of 0.1 or 0.2 g tributyl phosphate in olive oil
subcutaneous application: rabbits received 7 injections each other day of 0.1 g, 0.2 g or 1.0 g/kg/bw of tributyl phosphate

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl phosphate
EC Number:
204-800-2
EC Name:
Tributyl phosphate
Cas Number:
126-73-8
Molecular formula:
C12H27O4P
IUPAC Name:
tributyl phosphate
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: intraperitoneal or subcutaneous
Vehicle:
olive oil
Doses:
intraperitoneal application: 0.1 or 0.2 g tributyl phosphate
subcutaneous application: 0.1 g, 0.2 g or 1.0 g/kg/bw tributyl phosphate
No. of animals per sex per dose:
1 animal
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC0
Effect level:
100 mg/kg bw
Remarks on result:
other: ip injection - rabbit
Sex:
not specified
Dose descriptor:
LC0
Effect level:
200 mg/kg bw
Remarks on result:
other: sc injection rabbit

Any other information on results incl. tables

RM-Freetext:
rabbit, i.p.:100 mg/kg bw single injection: no effect
              200 mg/kg bw single injection: lethal after 11 days
             
rabbit, s.c.: 100 or 200 mg/kg bw: no systemic effects, proteinuria with 1000 mg/kg bw on 2 rabbits
               local inflammatory effects.

Applicant's summary and conclusion

Executive summary:

A single intraperitoneal injection of 100 mg/kg bw had no effect on rabbits, a single single intraperitoneal injection of 200 mg/kg bw

was lethal after 11 days.

Seven repeated subcutanous injections of 100 or 200 mg/kg bw caused no systemic effects, with 1000 mg/kg bw proteinuria
rabbit, s.c.: 100 or 200 mg/kg bw: no systemic effects, proteinuria with 1000 mg/kg bw on 2 rabbits. Local inflammatory effects on the injection side.