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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient data documentation
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1936

Materials and methods

Principles of method if other than guideline:
intraperitoneal application: one rabbit each received a single injection of 0.1 or 0.2 g tributyl phosphate in olive oil
subcutaneous application: rabbits received 7 injections each other day of 0.1 g, 0.2 g or 1.0 g/kg/bw of tributyl phosphate

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: intraperitoneal or subcutaneous
Vehicle:
olive oil
Doses:
intraperitoneal application: 0.1 or 0.2 g tributyl phosphate
subcutaneous application: 0.1 g, 0.2 g or 1.0 g/kg/bw tributyl phosphate
No. of animals per sex per dose:
1 animal
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC0
Effect level:
100 mg/kg bw
Remarks on result:
other: ip injection - rabbit
Sex:
not specified
Dose descriptor:
LC0
Effect level:
200 mg/kg bw
Remarks on result:
other: sc injection rabbit

Any other information on results incl. tables

RM-Freetext:
rabbit, i.p.:100 mg/kg bw single injection: no effect
              200 mg/kg bw single injection: lethal after 11 days
             
rabbit, s.c.: 100 or 200 mg/kg bw: no systemic effects, proteinuria with 1000 mg/kg bw on 2 rabbits
               local inflammatory effects.

Applicant's summary and conclusion

Executive summary:

A single intraperitoneal injection of 100 mg/kg bw had no effect on rabbits, a single single intraperitoneal injection of 200 mg/kg bw

was lethal after 11 days.

Seven repeated subcutanous injections of 100 or 200 mg/kg bw caused no systemic effects, with 1000 mg/kg bw proteinuria
rabbit, s.c.: 100 or 200 mg/kg bw: no systemic effects, proteinuria with 1000 mg/kg bw on 2 rabbits. Local inflammatory effects on the injection side.