Registration Dossier
Registration Dossier
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EC number: 204-800-2 | CAS number: 126-73-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient data documentation
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 936
Materials and methods
- Principles of method if other than guideline:
- intraperitoneal application: one rabbit each received a single injection of 0.1 or 0.2 g tributyl phosphate in olive oil
subcutaneous application: rabbits received 7 injections each other day of 0.1 g, 0.2 g or 1.0 g/kg/bw of tributyl phosphate
Test material
- Reference substance name:
- Tributyl phosphate
- EC Number:
- 204-800-2
- EC Name:
- Tributyl phosphate
- Cas Number:
- 126-73-8
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- tributyl phosphate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: intraperitoneal or subcutaneous
- Vehicle:
- olive oil
- Doses:
- intraperitoneal application: 0.1 or 0.2 g tributyl phosphate
subcutaneous application: 0.1 g, 0.2 g or 1.0 g/kg/bw tributyl phosphate - No. of animals per sex per dose:
- 1 animal
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 100 mg/kg bw
- Remarks on result:
- other: ip injection - rabbit
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 200 mg/kg bw
- Remarks on result:
- other: sc injection rabbit
Any other information on results incl. tables
RM-Freetext:
rabbit, i.p.:100 mg/kg bw single injection: no effect
200 mg/kg bw single injection: lethal after 11 days
rabbit, s.c.: 100 or 200 mg/kg bw: no systemic effects, proteinuria with
1000 mg/kg bw on 2 rabbits
local inflammatory effects.
Applicant's summary and conclusion
- Executive summary:
A single intraperitoneal injection of 100 mg/kg bw had no effect on rabbits, a single single intraperitoneal injection of 200 mg/kg bw
was lethal after 11 days.
Seven repeated subcutanous injections of 100 or 200 mg/kg bw caused no systemic effects, with 1000 mg/kg bw proteinuria
rabbit, s.c.: 100 or 200 mg/kg bw: no systemic effects, proteinuria with 1000 mg/kg bw on 2 rabbits. Local inflammatory effects on the injection side.
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