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Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: dermal, other
Remarks:
repeated application
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature - original in Russian
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Kalinina NI
Year:
1971
Bibliographic source:
Gig. Tr. Prof. Zabol. 15, 30-33

Materials and methods

Principles of method if other than guideline:
tributyl phosphate was applied repeated on the skin of rabbits, rats, and guinea pigs
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl phosphate
EC Number:
204-800-2
EC Name:
Tributyl phosphate
Cas Number:
126-73-8
Molecular formula:
C12H27O4P
IUPAC Name:
tributyl phosphate
Details on test material:
no data

Test animals

Species:
other: rabbits,rats, and guinea pigs
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
chronic poisoning
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
Basis:

No. of animals per sex per dose:
no data
Control animals:
other: no data specified
Details on study design:
Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:

purulent-necrotic fissures (no further data).

effects on central nervous system, liver and kidneys (no further data).

Applicant's summary and conclusion

Executive summary:

repeated application of tributyl ühosphate on the skin of rabbits, rats, and guinea pigs caused purulent-necrotic fissures and effects on the central nervous system, liver and kidneys. A NO(A)EL was not stated