Registration Dossier
Registration Dossier
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EC number: 204-800-2 | CAS number: 126-73-8
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal, other
- Remarks:
- repeated application
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature - original in Russian
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Kalinina NI
- Year:
- 1 971
- Bibliographic source:
- Gig. Tr. Prof. Zabol. 15, 30-33
Materials and methods
- Principles of method if other than guideline:
- tributyl phosphate was applied repeated on the skin of rabbits, rats, and guinea pigs
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tributyl phosphate
- EC Number:
- 204-800-2
- EC Name:
- Tributyl phosphate
- Cas Number:
- 126-73-8
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- tributyl phosphate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- other: rabbits,rats, and guinea pigs
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- chronic poisoning
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
purulent-necrotic fissures (no further data).
effects on central nervous system, liver and kidneys (no further data).
Applicant's summary and conclusion
- Executive summary:
repeated application of tributyl ühosphate on the skin of rabbits, rats, and guinea pigs caused purulent-necrotic fissures and effects on the central nervous system, liver and kidneys. A NO(A)EL was not stated
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