Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: dermal, other
Remarks:
repeated application
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature - original in Russian
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Kalinina NI
Year:
1971
Bibliographic source:
Gig. Tr. Prof. Zabol. 15, 30-33

Materials and methods

Principles of method if other than guideline:
tributyl phosphate was applied repeated on the skin of rabbits, rats, and guinea pigs
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl phosphate
EC Number:
204-800-2
EC Name:
Tributyl phosphate
Cas Number:
126-73-8
Molecular formula:
C12H27O4P
IUPAC Name:
tributyl phosphate
Details on test material:
no data

Test animals

Species:
other: rabbits,rats, and guinea pigs
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
chronic poisoning
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
Basis:

No. of animals per sex per dose:
no data
Control animals:
other: no data specified
Details on study design:
Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:

purulent-necrotic fissures (no further data).

effects on central nervous system, liver and kidneys (no further data).

Applicant's summary and conclusion

Executive summary:

repeated application of tributyl ühosphate on the skin of rabbits, rats, and guinea pigs caused purulent-necrotic fissures and effects on the central nervous system, liver and kidneys. A NO(A)EL was not stated