Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Currently viewing:

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: survey
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Occupational Health Guideline for dibutyl phosphate
Author:
Mackison FW ed., Stricoff RS, Partridge LJ Jr.
Year:
1981
Bibliographic source:
NIOSH/OSHA-Occupational Health Guidelines for Chemical Hazards, , DHHS (NIOSH) Publication No. 81-123, Washington, D.C. (1981)

Materials and methods

Study type:
not specified
Endpoint addressed:
other: effects of overexposure
Principles of method if other than guideline:
Health hazard informations from the US department of health and human services and the US department of labor
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl phosphate
EC Number:
204-800-2
EC Name:
Tributyl phosphate
Cas Number:
126-73-8
Molecular formula:
C12H27O4P
IUPAC Name:
tributyl phosphate

Method

Subjects:
worker
Reason of exposure:
unintentional, occupational

Results and discussion

Clinical signs:
Dibutyl hydrogen phosphate as metabolite of tributyl phosphate can affect the body if it is inhaled or if it comes in contact with eyes or skin. It can also affect the body if swallowed.

Any other information on results incl. tables

Short-term exposure: Dibutyl hydrogen phosphate may cause irritation of the eyes, nose, throat, and lungs. It also cause headaches.

Long-term expsoure: repeated or prolonged exposure may cause irritation of the skin

Applicant's summary and conclusion

Executive summary:

Short-term exposure: Dibutyl hydrogen phosphate may cause irritation of the eyes, nose, throat, and lungs. It also cause headaches.

Long-term expsoure: repeated or prolonged exposure may cause irritation of the skin.

Workers exposed to unspecified concentrations of vapor complained of respiratory irritation and headache.