Registration Dossier
Registration Dossier
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EC number: 204-800-2 | CAS number: 126-73-8
Endpoint summary
Administrative data
Description of key information
Two studies are available. Sasaki et al, 1982 determined BCF values in the range of 21-35 in Killifish and CITI, 1992 reported BCF values in the range of 5.5-20 in carp (6-8 weeks). The worst case approach (highest BCF of 35) was used to choose the key value for chemical safety assessment. Tributyl phosphate is thus considered as non-bioaccumulative in fish.
Additional information
The bioaccumulation of tributylphosphate was investigated in a continuous exposure system in Killifish (Sasaki et al, 1982). The test substance was taken up rapidly into the fish, reaching steady state within 24 hours. Levels remain constant for the remainder of the study. BCF values were calculated to be 21 -35. Following removal from the test water, elimination was rapid with a BH (biological half-life) value of 1.25 hours. Levels were below the lod at 24 hours.
The bioaccumulation of the substance from water was investigated in carp over a period of 6 -8 weeks (CITI, 1992). BCF values for fish of 6.9 -20 were calculated for the substance at a concentration of 6 µg/L in water; BCF values of 5.5 -10 were calculated for a concentration in water of 60 µg/L.
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