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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: validity of results not clear

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
HIV1-Virus is not inactivated by buthylated Hydroxytoluene (BHT) in vitro
Author:
Claeys H, Mercken M, Vermylen C
Year:
1988
Bibliographic source:
Med. Hypoth. 27, 145-146 (1988)
Reference Type:
publication
Title:
Tri(n-butyl) phosphate/detergent treatment of licensed therapeutic and experimental blood derivatives
Author:
Edwards CA, Piet MPJ, Chin S, Horowitz B
Year:
1987
Bibliographic source:
Vox Sang. 52, 53-59 (1987)
Reference Type:
publication
Title:
Large-scale production and properties of a solvent-detergent-treated factor IX concentrate from human plasma
Author:
Michalski C, Bal F, Burnouf T, Goudemand M
Year:
1988
Bibliographic source:
Vox Sang 55, 202-210 (1988)

Materials and methods

Principles of method if other than guideline:
Inactivation of viruses in human plasma was examined
GLP compliance:
no
Type of method:
in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl phosphate
EC Number:
204-800-2
EC Name:
Tributyl phosphate
Cas Number:
126-73-8
Molecular formula:
C12H27O4P
IUPAC Name:
tributyl phosphate
Details on test material:
no data

Test animals

Species:
other: not applicable
Strain:
other: not applicable
Sex:
not specified

Administration / exposure

Route of administration:
other: not applicable
Vehicle:
other: not applicable
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
not applicable
Frequency of treatment:
not applicable
Post exposure period:
not applicable
No. of animals per sex per dose:
not applicable

Results and discussion

Any other information on results incl. tables

Cytotoxicity in vitro: tributyl phosphate inactivate lipid-enveloped viruses, but did not alter the function of serum proteins.

Applicant's summary and conclusion