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EC number: 204-800-2 | CAS number: 126-73-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
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- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.13 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12.52 mg/m³
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.13 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12.52 mg/m³
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.44 mg/kg bw/day
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.78 mg/kg bw/day
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.44 mg/cm²
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.78 mg/cm²
Workers - Hazard for the eyes
Additional information - workers
Basis for delineation of the DNEL:
Study: Cancerogenicity study
Rat, male, female,
Cancerogenicity study over 2 years
rat: 0 (control), 200, 700 or 3000 ppm
(ca. 0,8.9, 32.5 or 143.2 mg/kg bw/d - male rats;
ca. 0, 11.6, 42 or 181.5 mg/kg bw/d - female rats) via diet.
NOAEL = 8.9 mg/kg bw/day (male rats), NOAEL = 11.6 mg/kg bw/day (female rats)
Effects: 200 ppm : based on the urinary bladder hyperplasia and neoplasms
Reference: Auletta CS, Richter WR (1994)
An oncogenicty study of tributyl phosphate in the rat via dietary
Bericht-Nr.: 89-3533
Pharmaco LSR Inc.
At the request of SOCMA (Synthetic Organic Chemical Manufacturers Association)
1.) Long-term toxicity – systemic effects (workers)
Long-term oral or dermal route-systemic effects (worker) using extrapolation factors:
NOAEL(rat) from a cancerogenicity study: 8.9 mg/kg bw/day
Penetration oral compared to dermal (both assumed 100%) 1
For interspecies differences rat vs. human: 4
For remaining interspecies differences: 1 (experimental data in rats, mice and rabbits available)
For intraspecies differences in workers: 5
For extrapolation of exposure duration: 1
For reliability of dose-response: 1
For quality of whole database: 1
Overall factor: 20
Worker DNEL long-term for oral or dermal route-systemic: 0.445 mg/kg bw/day
Long-term inhalation route-systemic effects (worker):
NOAEL(rat) from a cancerogenicity study: 8.9 mg/kg bw/day
Correction of the starting point according TGD Figure R.8-3:
Corrected inhalatory NOAEC = Oral NOAEL (8.9 mg/kg) x 1/0.38 m³/kg x 6.7 m³/10m³ x 1
=> NOAEC worker = 15.69 mg/m³
For interspecies differences rat vs. human: 1 (according TGD Table
R.8-4. already covered by correction of starting point)
For remaining interspecies differences: 1 (experimental data in rats, mice and rabbits available)
For intraspecies differences in workers: 5
For extrapolation of exposure duration: 1
For reliability of dose-response: 1
For quality of whole database: 1
Overall factor: 5
Worker DNEL long-term for inhalation exposure: 3.13 mg/m³
2.) Short-term toxicity – systemic effects (workers)
Concerning the systemic effects an exceeding factor of 4 based on the DNEL for long term exposure seems justified.
Therefore the
Worker DNELshort-term for oral or dermal route-systemic: 1.78 mg/kg bw/day
Worker DNEL short-term for inhalation exposure: 12.52 mg/m³
3.) Reproductive Toxicity – systemic effects (workers)
In a 2-generation toxicity study (EPA OTS 798.4700) with 700 and 3000 ppm reductions of body weights, weight gain and food consumption during F0 and F1 prebreed dosing periods , no signs of toxicity, no treatment related mortality; with 200 ppm only transient effects on body weight and food consumption. No NOAEL for adult toxicity. No evidence of reproductive organ histopathology at any dose, no effect on pre- and postnatal mortality. NOAEL for reproductive toxicity (reduced pup body weights) was at or below 200 ppm.
(NOAEL = approx.15 mg/kg bw/day (rats, male + female)
Tributyl phosphate was also investigated in a developmental toxicity feeding study in rats and rabbits:
Tributyl phosphate was administered by gastric intubation to rats during the day 6-15 gestation interval. Dose levels were 188, 375 and 750 mg/kg/day. Each study group was comprised of 24 mated female CD rats. Animals were sacrificed on day 20 of gestation and given a gross postmortem evaluation.
No embryotoxic effects were seen at any of the dose levels evaluated and only at the 750 mg/kg/day dose level was a reduction in mean fetal weight seen.
In groups treated at the 188 and 375 mg/kg/day dose levels, only mild developmental delays were seen in regard to both concurrent control data and historical control data.
No embryotoxic effects were seen at any of the dose levels evaluated and only at the 750 mg/kg/day dose level was a reduction in mean fetal weight seen.
External, visceral and skeletal examination of the fetuses recovered from females in the treatment groups at day 20 of gestation revealed no teratogenic response at any of the dose levels evaluated.
The NOAEL = 750 mg/kg bw for teratogenicity and embryotoxicity.
Tributyl phosphate was administrated by gastric intubation to mated New Zealand White rabbits (18 mated females/group) at dose levels of 50, 150 and 400 mg/kg/day during the day 6-18 gestation period. The 400 mg/kg/day dose level was not considered to be fetotoxic or teratogenic. At the 50 and 150 mg/kg/day dose levels was not considered to be maternally toxic, embryotoxic, fetotoxic or teratogenic in the rabbit. Thus, the no-observable-adverse-effect level (NOAEL)for developmental toxicity of tributyl phosphate in the rabbit for this study was 150 mg/kg bw/day.
The NOAEL for reproductive toxicity in rats is therefore approx. 15 mg/kg bw/day as the lower limit.
Additional or higher assessment factors than those used for the delineation of the DNEL from the cancerogenicity study are not necessary. As the NOAEL for reproductive toxicity (15 mg/kg bw/day) is higher than the NOAEL for cancerogenicity (8.9 mg/kg bw/day), the derivation of a separate DNEL for reproductive toxicity is not necessary, because the DNEL for cancerogenicity covers both endpoints.
The formal DNELs derived for reproductive toxicity are as follows:
Worker DNEL long-term for oral or dermal route-systemic: 0.75 mg/kg bw/day
Worker DNEL long-term for inhalation exposure-systemic: 5.27 mg/m³/day
Conclusion (systemic effects):
Worker DNEL long-term for oral or dermal route-systemic: 0.44 mg/kg bw/day
Worker DNEL long-term for inhalation exposure: 3.13 mg/m³
Worker DNELshort-term for oral or dermal route-systemic: 1.78 mg/kg bw/day
Worker DNEL short-term for inhalation exposure: 12.52 mg/m³
4. Long-term and short-term dermal or inhalation route - local effects (worker)
In rabbits, tributyl phosphate was slightly irritating to the skin (OECD TG 404), and slightly irritating to the eyes (OECD TG 405). The findings were not sufficient for classification.
In a guinea pig maximisation test (EPA OTS 798.4100) tributyl phosphate was negative.
Therefore the DNELs for systemic effects also applies to local effects:
Conclusion (local effects):
Worker DNEL long-term for oral or dermal route-local: 0.44 mg/kg bw/day
Worker DNEL long-term for inhalation exposure: 3.13 mg/m³
Worker DNELshort-term for oral or dermal route-local: 1.78 mg/kg bw/day
Worker DNEL short-term for inhalation exposure: 12.52 mg/m³
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.77 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.08 mg/m³
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.77 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.08 mg/m³
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.22 mg/kg bw/day
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.88 mg/kg bw/day
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.22 mg/cm²
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.88 mg/cm²
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.22 mg/kg bw/day
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.88 mg/kg bw/day
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Basis for delineation of the DNEL:
Study:
Cancerogenicity studyRat, male, female,
Cancerogenicity study over 2 years
rat: 0 (control), 200, 700 or 3000 ppm
(ca. 0,8.9, 32.5 or 143.2 mg/kg bw/d - male rats;
ca. 0, 11.6, 42 or 181.5 mg/kg bw/d - female rats) via diet.
Effects, NOAEL
NOAEL = 8.9 mg/kg bw/day (male rats), NOAEL = 11.6 mg/kg bw/day (female rats)
Effects: 200 ppm : based on the urinary bladder hyperplasia and neoplasms
Reference: Auletta CS, Richter WR (1994)
An oncogenicty study of tributyl phosphate in the rat via dietary
Bericht-Nr.: 89-3533
Pharmaco LSR Inc.
At the request of SOCMA (Synthetic Organic Chemical Manufacturers Association)
1.) Long-term toxicity – systemic effects (general population)
Long-term oral or dermal route-systemic effects (general population) using extrapolation factors:
NOAEL(rat) from a subchronic toxicity study: 8.9 mg/kg bw/day
Penetration oral compared to dermal (both assumed 100%) 1
For interspecies differences rat vs. human: 4
For remaining interspecies differences: 1 (experimental data in rats, mice and rabbits available)
For intraspecies differences in general population: 10
For extrapolation of exposure duration: 1
For reliability of dose-response: 1
For quality of whole database: 1
Overall factor: 40
General population DNEL long-term for oral or dermal route-systemic: 0.22 mg/kg bw/day
Long-term inhalation route-systemic effects (general population):
NOAEL(rat) from a cancerogenicity study: 8.9 mg/kg bw/day
Correction of the starting point according TGD Figure R.8-3:
Corrected inhalatory NOAEC = Oral NOAEL (8.9 mg/kg) x 1/1.15 m³/kg x 1.0
=> NOAEC general population = 7.73 mg/m³
For interspecies differences rat vs. human: 1 (according TGD Table
R.8-4. already covered by correction of starting point)
For remaining interspecies differences: 1 (experimental data in rats, mice and rabbits available)
For intraspecies differences in general population: 10
For reliability of dose-response: 1
For quality of whole database: 1
Overall factor: 10
General population DNEL long-term for inhalation exposure: 0.77 mg/m³
2.) Short-term toxicity – systemic effects (general population)
Concerning the systemic effects an exceeding factor of 4 based on the DNEL for long term exposure seems justified.
Therefore the
General population DNELshort-term for oral or dermal route-systemic: 0.88 mg/kg bw/day
General population DNEL short-term for inhalation exposure: 3.08 mg/m³
3.) Reproductive Toxicity – systemic effects (workers)
In a 2-generation toxicity study (EPA OTS 798.4700) with 700 and 3000 ppm reductions of body weights, weight gain and food consumption during F0 and F1 prebreed dosing periods , no signs of toxicity, no treatment related mortality; with 200 ppm only transient effects on body weight and food consumption. No NOAEL for adult toxicity. No ecidence of reproductive organ histopathology at any dose, no effect on pre- and postnatal nortality. NOAEL for reproductive toxicity (reduced pup body weights) was at or below 200 ppm.
(NOAEL = approx.15 mg/kg bw/day (rats, male + female)
Tributyl phosphate was also investigated in a developmental toxicity feeding study in rats and rabbits:
Tributyl phosphate was administered by gastric intubation to rats during the day 6-15 gestation interval. Dose levels were 188, 375 and 750 mg/kg/day. Each study group was comprised of 24 mated female CD rats. Animals were sacrificed on day 20 of gestation and given a gross postmortem evaluation.
No embryotoxic effects were seen at any of the dose levels evaluated and only at the 750 mg/kg/day dose level was a reduction in mean fetal weight seen.
In groups treated at the 188 and 375 mg/kg/day dose levels, only mild developmental delays were seen in regard to both concurrent control data and historical control data.
No embryotoxic effects were seen at any of the dose levels evaluated and only at the 750 mg/kg/day dose level was a reduction in mean fetal weight seen.
External, visceral and skeletal examination of the fetuses recovered from females in the treatment groups at day 20 of gestation revealed no teratogenic response at any of the dose levels evaluated.
The NOAEL = 750 mg/kg bw for teratogenicity and embryotoxicity.
Tributyl phosphate was administrated by gastric intubation to mated New Zealand White rabbits (18 mated females/group) at dose levels of 50, 150 and 400 mg/kg/day during the day 6-18 gestation period. The 400 mg/kg/day dose level was not considered to be fetotoxic or teratogenic. At the 50 and 150 mg/kg/day dose levels was not considered to be maternally toxic, embryotoxic, fetotoxic or teratogenic in the rabbit. Thus, the no-observable-adverse-effect level (NOAEL)for developmental toxicity of tributyl phosphate in the rabbit for this study was 150 mg/kg bw/day.
The NOAEL for reproductive toxicity in rats is therefore approx. 15 mg/kg bw/day as the lower limit.
Additional or higher assessment factors than those used for the delineation of the DNEL from the cancerogenicity study are not necessary. As the NOAEL for reproductive toxicity (15 mg/kg bw/day) is higher than the NOAEL for cancerogenicity (8.9 mg/kg bw/day), the derivation of a separate DNEL for reproductive toxicity is not necessary, because the DNEL for cancerogenicity covers both endpoints.
The formal DNELs derived for reproductive toxicity are as follows:
General population DNEL long-term for oral or dermal route-systemic: 0.37 mg/kg bw/day
General population DNEL long-term for inhalation exposure-systemic: 1.29 mg/m³/day
Conclusion (systemic effects):
General population DNEL long-term for oral or dermal route-systemic: 0.22 mg/kg bw/day
General population DNEL long-term for inhalation exposure: 0.77 mg/m³
General population DNELshort-term for oral or dermal route-systemic: 0.88 mg/kg bw/day
General population DNEL short-term for inhalation exposure: 3.08 mg/m³
4. Long-term and short-term dermal or inhalation route - local effects (worker)
In rabbits, tributyl phosphate was slightly irritating to the skin (OECD TG 404), and slightly irritating to the eyes (OECD TG 405). The findings were not sufficient for classification.
In a guinea pig maximisation test (EPA OTS 798.4100) tributyl phosphate was negative.
Therefore the DNELs for systemic effects also applies to local effects:
Conclusion (local effects):
General population DNELlong-term for oral or dermal route-local: 0.22 mg/kg bw/day
General population DNEL long-term for inhalation exposure: 0.77 mg/m³
General population DNELshort-term for oral or dermal route-local: 0.88 mg/kg bw/day
General population DNEL short-term for inhalation exposure: 3.08 mg/m³
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