Registration Dossier
Registration Dossier
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EC number: 204-800-2 | CAS number: 126-73-8
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: few experimental details - original in Russian
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Kalinina NI
- Year:
- 1 971
- Bibliographic source:
- Gig. Tr. Prof. Zabol. 15, 30-33
Materials and methods
- Principles of method if other than guideline:
- rats were exposed to vapour of tributyl phosphate at concentrations of 13.5+-2.5 and 4.8 mg/m³ for 4 month, 5 times per week, 5 hours daily. the cholinesterase activity and biochemical parameters were examined.
Test material
- Reference substance name:
- Tributyl phosphate
- EC Number:
- 204-800-2
- EC Name:
- Tributyl phosphate
- Cas Number:
- 126-73-8
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- tributyl phosphate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 months
- Frequency of treatment:
- 5 days/week, 5 hours/day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5.1 or 13.6 mg/m3
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: 1 months
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
in the high concentration decrease of cholinesteraseactivity to 33 % after 3 months, effects on physiological
and biochemical parameters esp. of the liver. The
cholinesterase activity retained to normal in the
postexposure period. In the low concentration no effect on
cholinesterase activity (no further data).
Applicant's summary and conclusion
- Executive summary:
Rats were exposed to vapour of tributyl phosphate at concentrations of 13.5+-2.5 amd 4.8 mg/m³ for 4 month, 5 times per week, 5 hours daily. The cholinesterase activity and biochemical parameters were examined.
in the high concentration decrease of cholinesteraseactivity to 33 % after 3 months, effects on physiological
and biochemical parameters esp. of the liver. The cholinesterase activity retained to normal in the
postexposure period. In the low concentration no effect on cholinesterase activity. A NO(A)EL was not stated.
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