Registration Dossier

Toxicological information

Repeated dose toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: few experimental details - original in Russian
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Kalinina NI
Year:
1971
Bibliographic source:
Gig. Tr. Prof. Zabol. 15, 30-33

Materials and methods

Principles of method if other than guideline:
rats were exposed to vapour of tributyl phosphate at concentrations of 13.5+-2.5 and 4.8 mg/m³ for 4 month, 5 times per week, 5 hours daily. the cholinesterase activity and biochemical parameters were examined.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Remarks on MMAD:
MMAD / GSD: no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 months
Frequency of treatment:
5 days/week, 5 hours/day
Doses / concentrations
Remarks:
Doses / Concentrations:
5.1 or 13.6 mg/m3
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: 1 months

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
in the high concentration decrease of cholinesteraseactivity to 33 % after 3 months, effects on physiological
and biochemical parameters esp. of the liver. The
cholinesterase activity retained to normal in the
postexposure period. In the low concentration no effect on
cholinesterase activity (no further data).

Applicant's summary and conclusion

Executive summary:

Rats were exposed to vapour of tributyl phosphate at concentrations of 13.5+-2.5 amd 4.8 mg/m³ for 4 month, 5 times per week, 5 hours daily. The cholinesterase activity and biochemical parameters were examined.

in the high concentration decrease of cholinesteraseactivity to 33 % after 3 months, effects on physiological
and biochemical parameters esp. of the liver. The cholinesterase activity retained to normal in the
postexposure period. In the low concentration no effect on cholinesterase activity. A NO(A)EL was not stated.