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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: few experimental details - but sufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Evaluation of delayed neurotoxicity and dose.response relationships of phosphate esters in the adult hen
Author:
Johannsen FR, Wright PL, Gordon DE, Levinskas RW, Radue RW, Graham PR
Year:
1977
Bibliographic source:
Toxicol. Appl. Pharmacol. 41, 291-304

Materials and methods

Principles of method if other than guideline:
undiluted test material was applied to intact, clipped skin (dorsal) of New Zealand albino male and female rabbits to determine the minimum lethal dose by the dermal route. Following application, treated areas were covered with plastic to preclude evaporation of the ester. Test material was washed off after the 24-hr exposure perid. animals were held for a 14-day observation period, after which they were sacrificed and subjected to gross autopsy.
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity > 97%, self made material

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not required

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 100 mg/kg bw
Remarks on result:
other: exposure: 24 hours

Any other information on results incl. tables

bo data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Executive summary:

undiluted test material was applied to intact, clipped skin (dorsal) of New Zealand albino male and female rabbits to determine the minimum lethal dose by the dermal route. Following application, treated areas were covered with plastic to preclude evaporation of the ester. Test material was washed off after the 24-hr exposure perid. animals were held for a 14-day observation period, after which they were sacrificed and subjected to gross autopsy.

LD50 > 3100 mg/kg bw (rabbit)

reference: Johannsen (1977)