Registration Dossier
Registration Dossier
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EC number: 204-800-2 | CAS number: 126-73-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: few experimental details - but sufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of delayed neurotoxicity and dose.response relationships of phosphate esters in the adult hen
- Author:
- Johannsen FR, Wright PL, Gordon DE, Levinskas RW, Radue RW, Graham PR
- Year:
- 1 977
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 41, 291-304
Materials and methods
- Principles of method if other than guideline:
- undiluted test material was applied to intact, clipped skin (dorsal) of New Zealand albino male and female rabbits to determine the minimum lethal dose by the dermal route. Following application, treated areas were covered with plastic to preclude evaporation of the ester. Test material was washed off after the 24-hr exposure perid. animals were held for a 14-day observation period, after which they were sacrificed and subjected to gross autopsy.
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- Tributyl phosphate
- EC Number:
- 204-800-2
- EC Name:
- Tributyl phosphate
- Cas Number:
- 126-73-8
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- tributyl phosphate
- Details on test material:
- purity > 97%, self made material
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 100 mg/kg bw
- Remarks on result:
- other: exposure: 24 hours
Any other information on results incl. tables
bo data
Applicant's summary and conclusion
- Executive summary:
Undiluted test material was applied to intact, clipped skin (dorsal) of New Zealand albino male and female rabbits to determine the minimum lethal dose by the dermal route. Following application, treated areas were covered with plastic to preclude evaporation of the ester. Test material was washed off after the 24-hr exposure perid. animals were held for a 14-day observation period, after which they were sacrificed and subjected to gross autopsy.
LD50 > 3100 mg/kg bw (rabbit)
reference: Johannsen (1977)
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