Registration Dossier

Administrative data

Description of key information

In 2 guideline studies tributyl phospahte was tested for skin irritation/corrosion and eye irritation. The test substance was found to be slightly irritating in both studies.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

The test substance was tested in a 4 h skin irritation/corrosion test in rabbits. The test substance (500 µl) was administered via patch to the radded skin of one flank and remained there for 4 hours. The other flank served as control and was treated only with water.

The animals were observed for 14 days after experiment. Mean value for erythema after DRAIZE-grade was: 1.8; mean value for edema: 0.7. The test substance was found to be slightly irritating.

The test substance was tested in a 24 h eye irritation test in rabbits. The test substance (100 µl) was administered into one eye of 3 rabbits (the other eye remained untreated and served as control). The substance was washed out after 24 hours with NaCl.

The animals were observed for 21 days after experiment.

The test substance was found to be slightly irritating to eye.


Effects on skin irritation/corrosion: slightly irritating

Effects on eye irritation: slightly irritating

Justification for classification or non-classification

skin irritation:

mean value for erythema = 1.8, mean value for oedema = 0.7

On the basis of this data a classification is not justified

eye irritation:

mean values for cornea opacity (0.7; 1.0; 0.0); mean values for iris inflammation (=.0; 0.0; 0.0);

mean values for conjunctivae reddening (1.0; 2.0; 1.0), mean values for conjunctivae swelling (0.3; 1.3; 0.0)

On the basis of this data a classification is not justified