Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-800-2 | CAS number: 126-73-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
- Reference Type:
- publication
- Title:
- Neurotoxicity studies in Sprague-Dawley rats with tributyl phosphate
- Author:
- Healy C, Beyrouty P, Losos G, Broxup BR
- Year:
- 1 992
- Bibliographic source:
- Toxicologist 12, 324 (1992)
- Reference Type:
- publication
- Title:
- Acute and subchronic neurotoxicity studies with tri-n-butyl phosphate in adult Sprague-Dawley rats
- Author:
- Healy CE, Beyrouty PC, Broxup BR
- Year:
- 1 995
- Bibliographic source:
- Am Ind Hyg Assoc J 56, 349-355
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.6050 (Neurotoxicity Screening Battery)
- Principles of method if other than guideline:
- Groups of 12 male and 12 female Sprague-Dawley rats were treated, by gavage, with tributyl phosphate (TBP) on a single occasion at dose levels of 100, 325 or 1000 mg/kg and then observed for 14 days. A control group was handled in an identical manner, except is was treated with the vehicle, corn oil, at the same dosage volume (10 ml/kg). The animals were examined using a functional observation battery (FOB) pre-study, at approximately 1 hour, 6 hours and 24 hours postdosing, and on observation days 7 and 14. Motor activity testing was conducted pre-study and on days 0 (approximately 11 hours following treatment), 7 and 14. Animals were subjected to a gross pathological examination at the completion of the study.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tributyl phosphate
- EC Number:
- 204-800-2
- EC Name:
- Tributyl phosphate
- Cas Number:
- 126-73-8
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- tributyl phosphate
- Details on test material:
- tributyl phosphate was received from FMC Corp.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- single treatment/ 14 d observation period
- Frequency of treatment:
- single treatment
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 100, 325 or 1000 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- 12 males and 12 females
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- other: NOAEL concerning neurotoxicity (single treatment/ 14 d observation period)
- Remarks on result:
- other:
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Executive summary:
Groups of 12 male and 12 female Sprague-Dawley rats were treated, by gavage, with tributyl phosphate (TBP) on a single occasion at dose levels of 100, 325 or 1000 mg/kg and then observed for 14 days. A control group was handled in an identical manner, except is was treated with the vehicle, corn oil, at the same dosage volume (10 ml/kg). The animals were examined using a functional observation battery (FOB) pre-study, at approximately 1 hour, 6 hours and 24 hours postdosing, and on observation days 7 and 14. Motor activity testing was conducted pre-study and on days 0 (approximately 11 hours following treatment), 7 and 14. Animals were subjected to a gross pathological examination at the completion of the study.
Dosages of 325 and 1000 mg/kg resulted in transient clinical changes and 1000 mg/kg resulted in transient decreases in male body weights, forelimb gripstrengh and motor activity levels for both sexes. The pattern of effects seen was attributed to an acute, non-specific toxicity without apparent neurotoxicity. No gross pathological findings were seen indicative of a treatment-related effect.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
