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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Remarks:
correlation of hypertension with organophosphate concentration in plasma of patients
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
hypertension in patients is correlated with organophosphate concentration in plasma - cross sectional study, no causality proven

Data source

Reference
Reference Type:
publication
Title:
Presence of organophosphate esters in plasma of patients with hypertension in Hubei Province, China
Author:
Li Y et al
Year:
2020
Bibliographic source:
Environmental Science and Pollution Research (2020) 27: 24059–24069

Materials and methods

Type of study / information:
cross sectional study

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl phosphate
EC Number:
204-800-2
EC Name:
Tributyl phosphate
Cas Number:
126-73-8
Molecular formula:
C12H27O4P
IUPAC Name:
tributyl phosphate

Results and discussion

Results:
Plasma probes of 232 hypertensive patients and 56 control donors of a hospital in Hubei, China were investigated. Tributyl phosphate was found in plasma of no patient, compared to 85.71% of control group (ND to 1.48 µg/mL; mean 0.76 µg/mL). No correlation with blood pressure was found for tributyl phosphate.

Applicant's summary and conclusion