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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Remarks:
correlation of hypertension with organophosphate concentration in plasma of patients
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
hypertension in patients is correlated with organophosphate concentration in plasma - cross sectional study, no causality proven

Data source

Reference
Reference Type:
publication
Title:
Presence of organophosphate esters in plasma of patients with hypertension in Hubei Province, China
Author:
Li Y et al
Year:
2020
Bibliographic source:
Environmental Science and Pollution Research (2020) 27: 24059–24069

Materials and methods

Type of study / information:
cross sectional study

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl phosphate
EC Number:
204-800-2
EC Name:
Tributyl phosphate
Cas Number:
126-73-8
Molecular formula:
C12H27O4P
IUPAC Name:
tributyl phosphate

Results and discussion

Results:
Plasma probes of 232 hypertensive patients and 56 control donors of a hospital in Hubei, China were investigated. Tributyl phosphate was found in plasma of no patient, compared to 85.71% of control group (ND to 1.48 µg/mL; mean 0.76 µg/mL). No correlation with blood pressure was found for tributyl phosphate.

Applicant's summary and conclusion