Registration Dossier
Registration Dossier
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EC number: 204-800-2 | CAS number: 126-73-8
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Remarks:
- correlation of hypertension with organophosphate concentration in plasma of patients
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- hypertension in patients is correlated with organophosphate concentration in plasma - cross sectional study, no causality proven
Data source
Reference
- Reference Type:
- publication
- Title:
- Presence of organophosphate esters in plasma of patients with hypertension in Hubei Province, China
- Author:
- Li Y et al
- Year:
- 2 020
- Bibliographic source:
- Environmental Science and Pollution Research (2020) 27: 24059–24069
Materials and methods
- Type of study / information:
- cross sectional study
Test material
- Reference substance name:
- Tributyl phosphate
- EC Number:
- 204-800-2
- EC Name:
- Tributyl phosphate
- Cas Number:
- 126-73-8
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- tributyl phosphate
Constituent 1
Results and discussion
- Results:
- Plasma probes of 232 hypertensive patients and 56 control donors of a hospital in Hubei, China were investigated. Tributyl phosphate was found in plasma of no patient, compared to 85.71% of control group (ND to 1.48 µg/mL; mean 0.76 µg/mL). No correlation with blood pressure was found for tributyl phosphate.
Applicant's summary and conclusion
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