Registration Dossier
Registration Dossier
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EC number: 204-800-2 | CAS number: 126-73-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a GPMT (guinea pig maximisation test) 0 out of 20 animals showed a positive reaction.
Migrated from Short description of key information:
Tributyl phosphate (0.3 ml of a 10% mixture in mineral oil) was applied topically to the left shoulders (previously clipped free of hair) of 10 male and 10 female Hartley guinea pigs (test group). The test material mixture was left in contact with the skin for approximately 6 hours. The animals received 3 induction treatments one week apart. A concurrent positive control group of 10 animals (5 male and 5 female) was treated in a similar manner with DNCB (Dinitrochlorobenzene) (0.15%). An additional 10 animals (5 male and 5 female) were treated in a similar manner with mineral oil as a vehicle control group.
14 days after the third induction treatment, the animals were challenged with the test material mixture at a virgin skin site on the right shoulder. An additional 5 male and 5 female naive animals received 0.3 ml of the test material mixture (challenge control group). The positive control group was challenged with DNCB. The vehicle control group was challenged with mineral oil. Observations for skin reactions were recorded at 24 and 48 hours after each application.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
no data
Migrated from Short description of key information:
no data available for respiratory sensitisation
Justification for classification or non-classification
In a GPMT the test material is juged to be non-sensitising when topically applied to hartley guinea pigs. Therefore a classification is not justified.
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