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EC number: 204-465-2
CAS number: 121-33-5
few data are available.
specific data are available on toxicity to reproduction, but the data
available on repeated dose toxicity studies indicated no effects on
teratogenicity studies were available on different species (mouse,
chicken, rat). Two of them were considered as validity 3 according to
Klimish scale. These studies were considered as validity 3, because of
the poor detail information on material and methods and results,
furthermore they did not follow the recognised OECD guidelines. However,
the results were similar and indicated no teratogen effects. The study
on rat (Vollmuth, 1990) is also poorly described but had been evaluated
by EFSA (European Food Safety Authority) and hence was considered as
validity 2. It did not follow an OECD guideline but could be considered
as teratogen study.
female rats per group were exposed one week before mating until 4 days
post partum to 0, 125, 250, 500 mg/kg bw/day of Vanillin. Maternal
toxicity had been reported with only few details: death, clinical signs
and change in body weight and feed consumption. The NOAEL maternal was
consider to be 250 mg/kg bw. No effect on pups were reported and the
NOEL for teratogenicity was the highest dose tested 500 mg/kg bw.
“weight of evidence” approach permit to consider that Vanillin had no
Regarding all the
available and according
criteria of EC regulation 1272/2008 Vanillin should not be
classified for reprotoxicity.
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