Registration Dossier
Registration Dossier
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EC number: 204-465-2 | CAS number: 121-33-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Few information are available about the test conditions and the results. Original reference in russian language.
Data source
Reference
- Reference Type:
- publication
- Title:
- Problem of the toxicity of vanillin
- Author:
- Makaruk MI
- Year:
- 1 980
- Bibliographic source:
- Gig Sanit, 6, 78-80
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Test type:
- other: no data
Test material
- Reference substance name:
- Vanillin
- EC Number:
- 204-465-2
- EC Name:
- Vanillin
- Cas Number:
- 121-33-5
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1-butoxypropan-2-ol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other:
- Details on inhalation exposure:
- >>> Generation of the test atmosphere:
* Chamber description:
- Exposure chamber volume: 100 L (no other information are available) - Duration of exposure:
- 4 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 41.7 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: rat
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 41.7 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 2 h
- Remarks on result:
- other: mouse
- Mortality:
- no mortality was observed
- Clinical signs:
- other: no data
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LC50 is above 41 mg/m3 which is the value of saturated vapour concentration.
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