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EC number: 204-465-2
CAS number: 121-33-5
a subchronic toxicity study (Anon., 1955) vanillin (purity unknown) was
administered to male Carworth Farms rats, 10/dose, in diet at dose
levels of 0, 1000, 5000, 10000 ppm.
No effect related to vanillin was observed.
The NOEL is 10000 ppm (equivalent to ca. 650 mg/kg bw/d).
In a repeated sub-chronic study, males and females rats were exposed daily to 0 or 10 000 ppm of vanillin by feed during 16 weeks. At 10 000 ppm, compared to the control group, there is no effect on body weight, haematological parameters and on gross pathology and histopathological findings.
Males and females rats were exposed by feed to vanillin during 27-28 weeks at 0 and 1000 ppm. Compared to the control group, there is no effect on body weight, haematological parameters, gross pathology and histopathological findings at 1000 ppm of vanillin.
Males dans females rats (12 animals/sex/dose) received 0, 5000, 20 000 or 50 000 ppm of vanillin by feed during 2 years. No effect were observed on body weight, haematological parameters, gross pathology and histological findings up to 20 000 ppm and compared to the control group.
Male rats were exposed by feed to vanillin (0, 20 000 and 50 000 ppm) during 1 year. Compared to the control group, there is no effect on body weight, haematological parameters, gross pathology and histophatological findings up to 50 000 ppm of vanillin.
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