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EC number: 204-465-2
CAS number: 121-33-5
Table 1: Number of animals dead and with evident toxicity, and range within which mortality occured for limit test
Mortality (# dead/total)
Time range of deaths (hours)
Number with evident toxicity(#/total)
Table 2: Number of animals dead and with evident toxicity, and time range within which mortality occurred for principal study
In an acute oral toxicity study (Lheritier, 1992), groups of fasted, 5-7 weeks old Sprague-Dawley rats (5/sex) were given a single oral dose of crystallised Vanilline (purity unknown) in CMC at doses of 0, 2000, 2510, 3160 and 3980 mg/kg bw and observed for 15 days. Lethargy, prostration or subdued behaviour were observed in all groups, and sialorrhea was observed in some animals. Death occurred in animals tested of main experiment: for limit test 2/10 at 2000 mg/kg bw for principal study : 0/10 at 0 mg/kg bw 1/10 at 2000 mg/kg bw 2/10 at 2510 mg/kg bw 3/10 at 3160 mg/kg bw 5/10 at 3980 mg/kg bw Oral LD50 Combined Males/Females = 3978 mg/kg bw (95% C.I. 2484 - 6368 mg/kg bw) according to Bliss' method
In the preliminary study, 3 groups of 2 males and 2 females/group were treated under the same conditions as those employed in the main study, at the dose levels of 500, 1000 and 2000 mg/kg. Animals were observed for 15 days. No clinical signs nor death were seen at all doses tested up to 2000 mg/kg in the preliminary study.
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