Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-465-2
CAS number: 121-33-5
Table 1: Number o
animals dead and with evident toxicity, and range within which mortality
occured for limit test
Mortality (# dead/total)
Time range of deaths (hours)
Number with evident toxicity(#/total)
Table 2: Number of
animals dead and with evident toxicity, and time range within which
mortality occurred for principal study
In an acute oral toxicity study (Lheritier,
1992), groups of fasted, 5-7 weeks old Sprague-Dawley rats (5/sex) were
given a single oral dose of crystallised Vanilline (purity unknown) in
CMC at doses of 0, 2000, 2510, 3160 and 3980 mg/kg bw and observed for
15 days. Lethargy, prostration or subdued behaviour were observed in all
groups, and sialorrhea was observed in some animals. Death occurred in
animals tested of main experiment: for limit test 2/10 at 2000 mg/kg bw
for principal study : 0/10 at 0 mg/kg bw 1/10 at 2000 mg/kg bw 2/10 at
2510 mg/kg bw 3/10 at 3160 mg/kg bw 5/10 at 3980 mg/kg bw Oral
LD50 Combined Males/Females = 3978 mg/kg bw (95% C.I. 2484 - 6368 mg/kg
bw) according to Bliss' method
In the preliminary study, 3 groups of 2
males and 2 females/group were treated under the same conditions as
those employed in the main study, at the dose levels of 500, 1000 and
2000 mg/kg. Animals were observed for 15 days
No clinical signs nor death were seen at all
dose level tested 2000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again