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EC number: 204-465-2
CAS number: 121-33-5
The immobilization of
daphnids (% relative to the control) are summarized in the table below:
Nominal concentration (mg/L)
Means of measured concentration (mg/L)
Geometric mean 0-24 h
Geometric mean 0-48 h
ND: not determined
parameters, including the EC50 and EC0 (i.e. NOEC), are
summarized in the table below:
Endpoints (mg/L) (1)
(1) EC100: lowest concentration with 100%
immobilization; EC50: Median (50%) Effective Concentration (numbers in
brackets correspond to the highest
concentration causing no immobilization and the lowest concentration
producing 100% immobilization);
EC0: highest concentration without immobilization
The 48 hours acute
toxicity of Vanilline to Daphnia magna was studied under static
conditions. Daphnids were exposed to test chemical at nominal
concentrations of 0, 5.62, 10, 17.8, 31.6, 56.2 and 100 mg/L for 48
hours. Immobilization and was observed .
The 48 hours EC50
was 36.79 mg/L.
The 48 hours NOEC
based on immobilization was 26.8 mg/L.
Based on the results
of this study, Vanilline is considered as harmful to Daphnia magna.
CIT report (2009) was chosen as key study, since conducted according to OECD guideline and GLP.Daphnids were exposed to test chemical at nominal concentrations of 0, 5.62, 10, 17.8, 31.6, 56.2 and 100 mg/L for 48 hours in static conditions. Immobilization was observed . The 48 hours EC50 was 36.79 mg/L, and the 48 hours NOEC was 26.8 mg/L.
Only one study on Vanilline was chosen as
key study, because it was conducted according to OECD guideline and GLP
on the results of this study, Vanilline is considered to be harmful to Daphnia
Another study on Natural Vanillin was chosen
as supporting study.
48-hours acute toxicity of Natural Vanillin (purity 98%) to Daphnia
magna was studied under static conditions. The
48-hours EC50 was higher than 10 mg/L but less than 100 mg/L (based on
on the results of this study, Natural Vanilline is considered to be
harmful to Daphnia magna.
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