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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
No information
Author:
CAUJOLLE, MEYNIER and MOSCARELLA
Year:
1953
Bibliographic source:
C R Hebdo Seanc Acad Sci, Paris, 236, 2549 (citation)
Reference Type:
review article or handbook
Title:
No information
Author:
CLAYTON GD, CLAYTON FE
Year:
1993
Bibliographic source:
Patty's Industrial Hygiene and Toxicology , 4th Edit Vol II.A, 445-525
Reference Type:
secondary source
Title:
No information
Author:
OPDYKE DLJ
Year:
1977
Bibliographic source:
Food Cosmet Toxicol, 15(6), 633-638
Reference Type:
secondary source
Title:
No information
Author:
CAUJOLLE, MEYNIER and FARTHOUAT
Year:
1956
Bibliographic source:
C R Hebdo Seanc Acad Sci, Paris, 243, 609 (citation)
Reference Type:
secondary source
Title:
No information
Author:
CAUJOLLE, MEYNIER and MOSCARELLA
Year:
1953
Bibliographic source:
C R Hebdo Seanc Acad Sci, Paris, 236, 2549 (citation)
Reference Type:
secondary source
Title:
No information
Author:
FRAZER
Year:
1967
Bibliographic source:
FAO/OMS Report Ser, vol 44A, 78 (citation)

Materials and methods

Principles of method if other than guideline:
See results
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Vanillin
EC Number:
204-465-2
EC Name:
Vanillin
Cas Number:
121-33-5
Molecular formula:
C8H8O3
IUPAC Name:
4-hydroxy-3-methoxybenzaldehyde
Details on test material:
no data

Test animals

Species:
other: see results

Administration / exposure

Route of administration:
other: see results

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 160 mg/kg bw
Remarks on result:
other: rat by i.p. route
Sex:
not specified
Dose descriptor:
LD50
Effect level:
780 mg/kg bw
Remarks on result:
other: mouse by i.p. route
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 190 mg/kg bw
Remarks on result:
other: guinea pig by i.p. route
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
1 320 mg/kg bw
Remarks on result:
other: dog by i.v. route
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 500 mg/kg bw
Remarks on result:
other: rat by s.c. route

Applicant's summary and conclusion