Registration Dossier
Registration Dossier
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EC number: 204-465-2 | CAS number: 121-33-5
Carcinogenicity
Administrative data
Description of key information
All available studies were not conducted according to recognized guidelines. In most of time the period of treatment was shorter than 2 years (from 8 days to 40 weeks), or only the tumor protective effects had been evaluated. These studies were not well described but in a "Weight of Evidence" approach, all results presented no carcinogenic effects.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Justification for classification or non-classification
In all available studies, the “Weight of Evidence” approach in carcinogenicity studies indicated that the results were negative and that Vanillin had no effect.
According to classification criteria of EC regulation 1272/2008 Vanillin should not be classified for carcinogenicity.
Additional information
Seven studies were available, four had reliability 3 and three had reliability 4. All available studies were not conducted according to recognized guidelines. In most of time the period of treatment was shorter than 2 years (from 8 days to 40 weeks), or only the tumor protective effects had been evaluated. These studies were not well described but in a "Weight of Evidence" approach, all results presented no carcinogenic effects with Vanillin.
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