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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Carcinogenicity

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Administrative data

Description of key information

All available studies were not conducted according to recognized guidelines. In most of time the period of treatment was shorter than 2 years (from 8 days to 40 weeks), or only the tumor protective effects had been evaluated. These studies were not well described but in a "Weight of Evidence" approach, all results presented no carcinogenic effects. 

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Justification for classification or non-classification


In all available studies, the “Weight of Evidence” approach in carcinogenicity studies indicated that the results were negative and that Vanillin had no effect.


According to classification criteria of EC regulation 1272/2008 Vanillin should not be classified for carcinogenicity.


Additional information

Seven studies were available, four had reliability 3 and three had reliability 4. All available studies were not conducted according to recognized guidelines. In most of time the period of treatment was shorter than 2 years (from 8 days to 40 weeks), or only the tumor protective effects had been evaluated. These studies were not well described but in a "Weight of Evidence" approach, all results presented no carcinogenic effects with Vanillin.