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EC number: 204-465-2
CAS number: 121-33-5
response data for each animal at each observation time:
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Average time (unit) for reversion
*) Reversibility: c. =
completely reversible; n.c.
= not completely reversible; n. = not reversible
In a primary eye irritation study (CIT, 2007) 100 mg of Vanilline (pure product) was instilled into the conjunctival sac of right eye of a young adult New Zealand White rabbit (3 males). Animals then were observed for 8 days (period of reversibility). Irritation was scored according to the OECD and EU guidelines.
Mean scores calculated for each animal over 24, 48 and 72 hours were 1.0, 1.7 and 2.0 for chemosis, 2.0, 2.0 and 2.0 for redness of the conjunctiva, 0.7, 0.7 and 0.3 for iris lesions and 2.0, 2.0 and 2.0 for corneal opacity.
In tis study, Vanillin is irritating to the eye based on EU classification criteria.
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