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EC number: 204-465-2
CAS number: 121-33-5
response data for each animal at each observation time:
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Average time (unit) for reversion
*) Reversibility: c. =
completely reversible; n.c.
= not completely reversible; n. = not reversible
In a primary eye irritation study
(CIT, 2007) 100 mg of Vanilline (pure product) was instilled into the
conjunctival sac of right eye of a young adult New Zealand White rabbit
(3 males). Animals then were observed for 8 days (period of
reversibility). Irritation was scored according to the OECD and EU
Mean scores calculated for each animal
over 24, 48 and 72 hours were 1.0, 1.7 and 2.0 for chemosis, 2.0, 2.0
and 2.0 for redness of the conjunctiva, 0.7, 0.7 and 0.3 for iris
lesions and 2.0, 2.0 and 2.0 for corneal opacity.
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