Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-465-2 | CAS number: 121-33-5
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- GAWORSKI CL, VOLLMUTH TA, DOZIER MM, HECK JD, DUNN LT, RATAJCZAK HV, THOMAS PT
- Year:
- 1 994
- Bibliographic source:
- Food Chem Toxicol, 32(5), 409-415
Materials and methods
- Limit test:
- no
Test material
- Reference substance name:
- Vanillin
- EC Number:
- 204-465-2
- EC Name:
- Vanillin
- Cas Number:
- 121-33-5
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1-butoxypropan-2-ol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: methylcellulose
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 5 days
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 250 mg/kg bw/day
- Dose / conc.:
- 500 mg/kg bw/day
- Dose / conc.:
- 1 000 mg/kg bw/day
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- positive control group: host resistance to Listeria monocytogenes
Results and discussion
Results of examinations
- Details on results:
- In female CD-1 mice (30 mice/group) dosed intragastrically at 3 concentrations: 1000, 500, and 250 mg/kg/day Vanillin, and vehicle control
(1% methylcellulose) for 5 consecutive days; control untreated group, positive control group: host resistance to Listeria monocytogenes;
Anti-sheep red blood cell (SRBC) plaque-forming cell (PFC) assay: specific cellular activity, and total speen activity;
no significant difference in treated group by Vanillin from untreated control group.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
