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EC number: 204-465-2
CAS number: 121-33-5
Table 1: Number of
animals dead during limit test
Mortality (# dead/total)
Time range of deaths (hours)
Table 2: Number of
animals dead and with evident toxicity for principal study =
Number with evident toxicity(#/total)
In an acute dermal
toxicity study (Hazleton, 1991), groups of 5 -7 weeks old Sprague-Dawley
rats (male / female) were dermally exposed to Vanilline for 24 hours to
approximately 10% area of the body at doses of 2000 mg/kg bw. Animals
then were observed for 14 days.
In the preliminary
study, 2 males and 2 femalesper group were treated under the same
conditions as those employed in the main study, at the dose levels of
1000 and 2000 mg/kg. No deaths were seen at all dose level tested of
Dermal LD50 Combined >
2000mg/kg bw. No clinical sign, except yellowish coloration of the
skin and no mortality occurred at this dose.
criteria of EC regulation 1272/2008 Vanillin should not be classified
for acute dermal toxicity based on
the LD50 in male and female rats.
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