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EC number: 204-428-0 | CAS number: 120-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented publication which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Repeated Topical Applications of 1,2,4-Trichlorobenzene
- Author:
- Powers MB, Coate WB, Lewis TR
- Year:
- 1 975
- Bibliographic source:
- Arch Environ Health 30: 165-167.
Materials and methods
- Principles of method if other than guideline:
- Increasing concentrations of 1,2,4-trichlorobenzene were applied topically to the ventral surface of the rabbit ear three times weekly for 13 weeks.
Additional groups of rabbits received similar treatment with petroleum ether (solvent controls), received no treatment (negative controls), and received four once-weekly treatments with hexachlorodiphenyloxide, a known chloracnegenic agent (positive controls) - GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
- Limit test:
- no
Test material
- Reference substance name:
- 1,2,4-trichlorobenzene
- EC Number:
- 204-428-0
- EC Name:
- 1,2,4-trichlorobenzene
- Cas Number:
- 120-82-1
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,4-trichlorobenzene
- Details on test material:
- -Name of test material (as cited in study report): 1,2,4-trichlorobenzene
-Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Acclimation period: 2 weeks
Administration / exposure
- Type of coverage:
- other: see any other information on materials and methods incl. tables
- Vehicle:
- other: petroleum ether
- Details on exposure:
- TEST SITE
- Area of exposure: inner surface of one ear
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): test solutions were applied at the rate of 0.2 mL per exposure.
VEHICLE
- Amount(s) applied (volume or weight with unit): solvent was applied at the rate of 0.2 mL per exposure
POSITIVE CONTROL:
Amount(s) applied (volume or weight with unit): Hexachlorodiphenyloxide was applied as a 10% emulsion in olive oil - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- 3 times per week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5, 25 or 100 % test substance solution per application
Basis:
no data
- No. of animals per sex per dose:
- see any other information on materials and methods incl. tables
- Control animals:
- yes, concurrent no treatment
- yes, concurrent vehicle
- other: positive control
- Positive control:
- hexachlorodiphenyloxide
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Gross pathology
At necropsy, performed on all animals, all positive control rabbits showed gross hepatic changes: the livers appeared rough, granular, tough, yellowish-brown in color and in two rabbits, margins were much thickened and yellowish-areas were noted throughout the organ. The negative control, solvent control, and test animals did not show meaningful visceral changes at necropsy.
Microscopic pathology
With the regard to the effect on the skin see Endpoint 7.3.1, key, 2, Powers, rabbit, IUC4.
Sections of liver, kidney, spleen and bone marrow from hexachlorodiphenyloxide-exposed rabbits revealed hepatic damage in all animals characterized by focal hepatocyte hypertrophy, focal necrosis, fibrosis and bile stasis, toxic tubular degeneration of the kidney on one rabbit, lymphoid atrophy of the spleen in one animal, and hypocellularity (hypoplasia) of the bone marrow in all animals. Visceral lesions in the remaining animals were not remarkable and were consistent with spontaneous disease.
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