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EC number: 204-428-0 | CAS number: 120-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
Bioaccumulation aquatic/ sediment
With a logKow >4.0, 1,2,4-TCB has a bioaccumulation potential. This was confirmed by several tests on different fish species and other aquatic species. The bioconcentration factor BCF for fish/water (whole body) is according to the realistic worstcase concept approximately 2000. Biological concentration factors of 50 - 2300 (Smith et al., 1981), calculated on fresh weight, and of up to 23790 (Geyer et al., 1985), calculated on fat content, have been found. In an experimental study similar to OECD guideline 305C, the BCF value in Cyprinus carpio after exposure to 1,2,4-TCB over a period of 56d was determined at two dose levels (0.04 and 0.004 mg/L) revealing values between 805 (whole body) and 17303 (total liquid content) (Markert, 1984).
The available data indicate that 1,2,4-trichlorobenzene can be considered as potentially accumulative (BCF values over 2000 were reported).
Bioaccumulation terrestrial
The accumulation in earthworms was studied by Beyer (1996) in a standard soil (69.7% sand, 20% clay, 10% peat and 0.3% CaCO3) where clitellate, i.e. sexually mature, Lumbricus terrestris were exposed to 10 ppm 1,2,4-TCB during 8 and 26 weeks. The BCF was 0.09 in the 8-week experiment and 0.06 in the 26-week experiment (Beyer, 1996). Because of 1,2,4 -TCB's high adsorption capacity and the high-soil organic matter content in the study, BCF would be expected to be lower than under most field conditions. Taking these results into consideration, results from other organochlorines including hexachlorobenzene indicate according to Beyer (1996) that BCF of 1,2,4-TCB for earthworms may be around 1 in soil with normal ranges of organic matter. Beyer (1996) shows that BCF earthworm for chlorobenzenes increases with the degree of chlorination and that the BCF of hexachlorobenzene for Lumbricus terrestris was 0.27. He compares this result in a study with an OECD standard soil with 10% organic matter with a study where a BCF for Lumbricus terrestris was 2 to 3 in a soil with 2.6% organic matter (Lord et al., 1980).
In comparison by employing the equilibrium method, the bioconcentration factor for earthworm, according to the TGD (equations 62 and 63) and taking the soil-water partition coefficient into account, is estimated to be: BCF earthworm = K earthworm-porewater . ((RHOsoil.10-3)/Ksoil-water) = 0.25.0.16.Kow.(1.700/42.2) =18; i.e an order of magnitude higher than the BCF based on experimental data, which however is regarded more reliable, because of the existence of comparable results in several studies with other chlorinated benzenes.
Additional information
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