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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Mutagenicity characteristics of 255 environmental chemicals.
Author:
Kubo T, Urano K, Utsumi H
Year:
2002
Bibliographic source:
J Health Sci 48(6): 545–554.

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,4-trichlorobenzene
EC Number:
204-428-0
EC Name:
1,2,4-trichlorobenzene
Cas Number:
120-82-1
Molecular formula:
C6H3Cl3
IUPAC Name:
1,2,4-trichlorobenzene
Test material form:
not specified

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium TA 97
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Species / strain:
S. typhimurium TA 100
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results: negative
Executive summary:

The result of the salmonella mutagenicity test of 1,2,4-TCB for both strains TA97 and TA100 were negative