Registration Dossier
Registration Dossier
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EC number: 204-428-0 | CAS number: 120-82-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagenicity characteristics of 255 environmental chemicals.
- Author:
- Kubo T, Urano K, Utsumi H
- Year:
- 2 002
- Bibliographic source:
- J Health Sci 48(6): 545–554.
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2,4-trichlorobenzene
- EC Number:
- 204-428-0
- EC Name:
- 1,2,4-trichlorobenzene
- Cas Number:
- 120-82-1
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,4-trichlorobenzene
- Test material form:
- not specified
Constituent 1
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 97
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
- Executive summary:
The result of the salmonella mutagenicity test of 1,2,4-TCB for both strains TA97 and TA100 were negative
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