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EC number: 204-428-0 | CAS number: 120-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed source, valid collection of data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Water solubility:
- 0.019 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: The pH value was not reported.
- Executive summary:
Roempp, 2009
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 19 mg/L at 20 °C. The pH value was not reported.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Water solubility:
- 31.3 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: The pH value was not reported.
- Executive summary:
HSDB, 2009
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 31.3 mg/L at 25 °C. The pH value was not reported.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed source, valid collection of data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Water solubility:
- 37.8 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: The pH value was not reported.
- Details on results:
- this value is calculated from the value as cited in the literature (0.00379 mass%)
- Executive summary:
Lide, 2001
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 37.8 mg/L at 25 °C. The pH value was not reported.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: na data
- Specific details on test material used for the study:
- analytical purity: not specified
- Water solubility:
- ca. 0.04 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: The pH value was not reported.
- Executive summary:
Hommel, 1994
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 40 mg/L at 20 °C. The pH value was not reported.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Water solubility:
- 0.03 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: The pH value was not reported.
- Executive summary:
Rippen, 1991
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 30 mg/L at 20 °C. The pH value was not reported.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Water solubility:
- 45.3 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: The pH value was not reported.
- Executive summary:
Miller, 1984
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 45.3 mg/L at 25 °C. The pH value was not reported.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Water solubility:
- 34.6 mg/L
- Remarks on result:
- other: The temperature and pH value were not reported.
- Executive summary:
EPA, 1985
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 34.6 mg/L. The temperature and pH value were not reported.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Water solubility:
- 0.019 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: The pH value was not reported.
- Executive summary:
UBA, 1984
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 19 mg/L at 20 °C. The pH value was not reported.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.
- Principles of method if other than guideline:
- secondary peer reviewed scoure, valid collection af data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Specific details on test material used for the study:
- analytical purity: not specified
- Water solubility:
- 30 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: The pH value was not reported.
- Executive summary:
Hooftman, 1982
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 30 mg/L at 25 °C. The pH value was not reported.
Referenceopen allclose all
pH was not reported.
pH was not reported.
no further data on pH
Description of key information
The individual study reports (data from handbooks or collection of data and (QSAR)calculations) show some deficiencies with respect to the comprehensiveness of the experimental details. Therefore, a reliability of 1 or 2 and thus adequacy as key study was not assignable for any of the individual studies. Consequently, the studies were assigned a Klimisch score of 4 (according to guidance document R.4, ‘not assignable: studies or data […] which are only listed in short abstracts or secondary literature (books, reviews, etc.)). As the individual studies report values are in a similar range, collectively, these studies can be used to conclude on this endpoint and to satisfy the information requirement.
The water solubility of 1,2,4-trichlorobenzene has been determined in a series of experimental studies and ranges from 19 mg/L to 40 mg/L at a temperature of 20 °C. The mean value of 29.5 mg/L at 20 °C was chosen as key value for chemical safety assessment.
At a temperature of 25 °C, the water solubility is reported to be between 30 mg/L and 45.3 mg/L. The pH value was not reported.
Roempp, 2009
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 19 mg/L at 20 °C. The pH value was not reported.
HSDB, 2009
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 31.3 mg/L at 25 °C. The pH value was not reported.
Lide, 2001
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 37.8 mg/L at 25 °C. The pH value was not reported.
Hommel, 1994
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 40 mg/L at 20 °C. The pH value was not reported.
Rippen, 1991
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 30 mg/L at 20 °C. The pH value was not reported.
Miller, 1984
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 45.3 mg/L at 25 °C. The pH value was not reported.
EPA, 1985
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 34.6 mg/L. The temperature and pH value were not reported.
UBA, 1984
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 19 mg/L at 20 °C. The pH value was not reported.
Hooftman, 1982
The water solubility of 1,2,4-trichlorobenzene was determined in an experimental study as 30 mg/L at 25 °C. The pH value was not reported.
Key value for chemical safety assessment
- Water solubility:
- 29.5 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.