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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable documented publication

Data source

Referenceopen allclose all

Title:
No information
Author:
DOW Chem. Co (1977), Subchronic Toxicity study of inhaled|1.2.4-trichlorobenzene in rats, NTIS/OTS 84003A, Doc ID.|87821105
Title:
No information
Author:
Watanabe, P.G. et al. (1978): Toxicol. Appl. Pharmacol. 45,|332 - 333

Materials and methods

Principles of method if other than guideline:
Method: other: 26 females/10 males/dose group, interim kill at 0.5, 1, 2, 3 months, gross necropsies
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Reference substance 001
Details on test material:
IUCLID4 Test substance: other TS: purity: 99.6 %

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
90 days
Frequency of treatment:
6 hours/day, 5 days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
3 or 10 ppm (24 or 80 mg/m3)
Basis:

Control animals:
yes, concurrent no treatment
Details on study design:
Post-exposure period: 2 to 4 months

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
3 ppm
Sex:
male/female

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion