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EC number: 204-428-0 | CAS number: 120-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to other aquatic organisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to other aquatic vertebrates
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other: EU Risk Assessment
- Rationale for reliability incl. deficiencies:
- other: No reliability is given as this is a summary entry for the EU RAR.
- Principles of method if other than guideline:
- EU Risk Assessment
- GLP compliance:
- not specified
- Executive summary:
EU Risk Assessment (2003):
Short-term toxicity to Tetrahymena pyriformis (freshwater aquatic protozoa), Tanytarsus dissmilis (chironomid midge) and Aplexa hypnorum (snail) was studied by Yoshioka et al. (1985) and Holcombe et al. (1987). They found EC50 values ranging from 0,91 mg/l (protozoa) to 3,16 mg/l (snail).
- Endpoint:
- toxicity to other aquatic vertebrates
- Type of information:
- other: BUA report
- Adequacy of study:
- other information
- Reliability:
- other: BUA report
- Rationale for reliability incl. deficiencies:
- other: No reliability is given as this is a summary entry for the BUA report.
- Principles of method if other than guideline:
- BUA report
- GLP compliance:
- not specified
- Executive summary:
BUA report (1987):
In a test on Tetrahymena pyriformisan EC50 of 0,91 mg/l was determined after 24 h test duration (Yoshioka et al., 1985).
In a flow-through test on Branchiostoma caribaeum after 96 hours a LC0 of 1,5 mg/l and a LC100 of 10 mg/l was found. When 1,2,4-TCB was added to the test system via sediment after 10 days the following toxic endpoints were found: LC0 = 75 mg/kg, LC50 = 200 mg/kg and LC100 = 240 mg/kg (Clark et al., 1987).
In a test on teratogenicity 1,2,4-TCB showed an effected on the larval development of Artemia salina (Kerster and Schaeffer, 1983).
Referenceopen allclose all
EU Risk Assessment (2003):
Short-term toxicity to Tetrahymena pyriformis (freshwater aquatic protozoa), Tanytarsus dissmilis (chironomid midge) and Aplexa hypnorum (snail) was studied by Yoshioka et al. (1985) and Holcombe et al. (1987). They found EC50 values ranging from 0,91 mg/l (protozoa) to 3,16 mg/l (snail).
BUA report (1987):
In a test on Tetrahymena pyriformisan EC50 of 0,91 mg/l was determined after 24 h test duration (Yoshioka et al., 1985).
In a flow-through test on Branchiostoma caribaeum after 96 hours a LC0 of 1,5 mg/l and a LC100 of 10 mg/l was found. When 1,2,4-TCB was added to the test system via sediment after 10 days the following toxic endpoints were found: LC0 = 75 mg/kg, LC50 = 200 mg/kg and LC100 = 240 mg/kg (Clark et al., 1987).
In a test on teratogenicity 1,2,4-TCB showed an effected on the larval development of Artemia salina (Kerster and Schaeffer, 1983).
Description of key information
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
Studies were performed in different test species (Tetrahymena pyriformisan, Branchiostoma caribaeum, Artemia salina, Tanytarsus dissmilis, Aplexa hypnorum), with varying exposure times and revealed following values:
EC50: 0.91 - 3.16 mg/L
LC0: 1.5 mg/L
LC100: 10 mg/L
BUA report (1987):
In a test on Tetrahymena pyriformisan EC50 of 0,91 mg/l was determined after 24 h test duration (Yoshioka et al., 1985).
In a flow-through test on Branchiostoma caribaeum after 96 hours a LC0 of 1,5 mg/L and a LC100 of 10 mg/L was found. When 1,2,4-TCB was added to the test system via sediment after 10 days the following toxic endpoints were found: LC0 = 75 mg/kg, LC50 = 200 mg/kg and LC100 = 240 mg/kg (Clark et al., 1987).
In a test on teratogenicity 1,2,4-TCB showed an effected on the larval development of Artemia salina (Kerster and Schaeffer, 1983).
EU Risk Assessment (2003):
Short-term toxicity to Tetrahymena pyriformis (freshwater aquatic protozoa), Tanytarsus dissmilis (chironomid midge) and Aplexa hypnorum (snail) was studied by Yoshioka et al. (1985) and Holcombe et al. (1987). They found EC50 values ranging from 0,91 mg/L (protozoa) to 3,16 mg/L (snail).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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