Registration Dossier
Registration Dossier
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EC number: 204-428-0 | CAS number: 120-82-1
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- other: not specified if calculated or experimental result
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference is not available.
- GLP compliance:
- not specified
- Executive summary:
Rippen, 1991
pH = 9 kB < 10e-4 L mol(e-1) h(e-1); half-life > 1 a
1,2,4-Trichlorobenzene will not hydrolyze under environmental conditions.- Endpoint:
- hydrolysis
- Type of information:
- other: scientific judgement
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference is not available.
- GLP compliance:
- not specified
- Executive summary:
Howard, 1991
t1/2: 3.4 years, scientific judgement based upon overall rate constant (2.3 x 10e-5 he-1) at pH 7 and 25 °C (Ellington, J.J. et al. 1988)
- Endpoint:
- hydrolysis
- Type of information:
- other: BUA report
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Executive summary:
BUA report (1987):
1,2,4-trichlorobenzene is not hydrolysable under the conditions existing in the environment.
- Endpoint:
- hydrolysis
- Type of information:
- other: not specified if calculated or experimental result
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference is not available.
- GLP compliance:
- not specified
- Executive summary:
Umweltbundesamt (UBA), 1986
t1/2 pH 3: 1806 h at 50 °C
t1/2 pH 7: 4577 h at 50 °C
t1/2 pH 9: 6889 h at 50 °C- Endpoint:
- hydrolysis
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other: EU Risk Assessment
- Rationale for reliability incl. deficiencies:
- other: No reliability is given as this is a summary entry for the EU RAR.
- GLP compliance:
- not specified
- Executive summary:
EU Risk Assessment (2003):
EU RAR, page: 24
Based on the experimental data (Korte and Freitag, 1986) on hydrolysis at 50°C,1,2,4-TCB is not expected to hydrolyse under normal environmental conditions (Howard, 1989; Schmidt-Bleek et al., 1982).
EU RAR, page: 8
The hydrolysis was studied in buffer solutions at pH 3, 7 and 9 using radioactive 1,2,4-TCB at the initial concentration of 17.7 mg/l. During a study period of 5 days, the half-lives of 1,2,4 TCB at 50°C were estimated to be 1,806 hours (75 days) at pH 3, 4,577 hours (190 days) at pH 7 and 6,889 hours (287 days) at pH 9 (Korte and Freitag, 1986). The large half-lives for hydrolysis which indicate hydrolytic stability mean that it has not been taken into account in the risk assessment.
Referenceopen allclose all
t1/2: 3.4 years
BUA report (1987):
1,2,4-trichlorobenzene is not hydrolysable under the conditions existing in the environment.
Description of key information
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
EU Risk Assessment (2003):
EU RAR, page: 24
Based on the experimental data (Korte and Freitag, 1986) on hydrolysis at 50°C,1,2,4-TCB is not expected to hydrolyse under normal environmental conditions (Howard, 1989; Schmidt-Bleek et al., 1982).
EU RAR, page: 8
The hydrolysis was studied in buffer solutions at pH 3, 7 and 9 using radioactive 1,2,4-TCB at the initial concentration of 17.7 mg/l. During a study period of 5 days, the half-lives of 1,2,4 TCB at 50°C were estimated to be 1,806 hours (75 days) at pH 3, 4,577 hours (190 days) at pH 7 and 6,889 hours (287 days) at pH 9 (Korte and Freitag, 1986). The large half-lives for hydrolysis which indicate hydrolytic stability mean that it has not been taken into account in the risk assessment.
BUA report (1987):
1,2,4-trichlorobenzene is not hydrolysable under the conditions existing in the environment.
Howard, 1991:
t1/2: 3.4 years, scientific judgement based upon overall rate constant (2.3 x 10e-5 he-1) at pH 7 and 25 °C (Ellington, J.J. et al. 1988)
Rippen, 1991:
pH = 9 kB < 10e-4 L mol(e-1) h(e-1); half-life > 1 a
1,2,4-Trichlorobenzene will not hydrolyze under environmental conditions.
Umweltbundesamt (UBA), 1986:
t1/2 pH 3: 1806 h at 50 °C
t1/2 pH 7: 4577 h at 50 °C
t1/2 pH 9: 6889 h at 50 °C
Key value for chemical safety assessment
Additional information
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