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EC number: 202-500-6
CAS number: 96-33-3
Methyl acrylate showed no evidence of carcinogenicity in a 2-year vapour inhalation study in Sprague-Dawley rats up to the highest tested dose (135 ppm = 0.519 mg/L).
EU classification according to Regulation (EC) No. 1272/2008: no
Sprague-Dawley rats (86/sex/group) were
exposed to methyl acrylate vapour at 15, 45, or 135 ppm (0.058, 0.173,
0.519 mg/L/), 6 hrs/day, 5 days/week for 2 years. During the initial
13-week period, the concentrations were 5, 15 and 45 ppm (0.019, 0.058,
0.173 mg/L). One group of 86 rats/sex was exposed to air and served as
control. Interim kills were performed after 12 and 18 months of exposure
(BASF AG 1985, Reininghaus et al. 1991). A temporary retardation of body
weight gain was observed in the high-dose group. Dose-related
degeneration of the olfactory epithelium (primarily the anterior
portion) and a subsequent regeneration and replacement with respiratory
epithelium was also observed at the highest dose. No differences in the
incidences of preneoplastic or neoplastic lesions were observed between
control and exposed groups. (see also Section 7.5 Repeated Dose Toxicity)
Methyl acrylate was not carcinogenic in
an adequately performed 2-year inhalation study in Sprague-Dawley rats
up to the highest tested dose (135 ppm = 0.519 mg/L).
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