Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
cytotoxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented study

Data source

Reference
Reference Type:
publication
Title:
Acrylate and methacrylate esters: Relationship of hemolytic activity and in vivo toxicity.
Author:
Dillingham EO et al.
Year:
1983
Bibliographic source:
J. Biomed. Mat. Res. 17: 945-957

Materials and methods

Principles of method if other than guideline:
According to Higuchi and Davis(1970) and Dillingham et al. (1973).
GLP compliance:
not specified
Type of method:
in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl acrylate
EC Number:
202-500-6
EC Name:
Methyl acrylate
Cas Number:
96-33-3
Molecular formula:
C4H6O2
IUPAC Name:
methyl acrylate
Details on test material:
Methyl acrylate, no further data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Results and discussion

Details on results:
The concentration effecting 50 % hemolysis in rabbit erythrocytes in vitro was determined to be 20 g/L (0.23 mole/L).

Applicant's summary and conclusion