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EC number: 202-500-6
CAS number: 96-33-3
Methyl acrylate is acutely toxic to freshwater algae.EC50 (72 h, growth rate) = 3.55 mg/L (measured) (Selenastrum capricornutum, OECD TG 201)
An acute toxicity
study was conducted withSelenastrum capricornutum (BAMM, 1995)
according to OECD Guideline 201 using a static design. Nominal exposure
concentrations were 0.60, 1.2, 2.4, 4.8, 9.5, 19, 38 mg/L. At time 0,
the analyzed concentrations were 0.62, 1.3, 2.5, 4.2, 9.5, 19 and 34
mg/L. After 72 and 96 hours, analyses of the test media were all below
the limit of quantification (LOQ) for the methodology (0.25 mg/L). Based
upon the decline in test substance concentration over the 96-hour
exposure period, the test results were presented based on 0-hour
measured concentrations in the original report.
Thus, a recalculation
of the more realistic effect values concerning growth rate was
additionally performed taking the arithmetic means of the measured
concentrations and the measured inhibition. Arithmetical means of the
concentrations were 0.225, 0.325, 0.625, 1.5, 2.52, 4.75, and 12.08 mg
methyl acrylate/L for the nominal concentrations of 0.60, 1.2, 2.4, 4.8,
9.5, 19 and 38 mg methyl acrylate/L. Missing 24 h measurements were
considered to be 0 mg/L as worst case scenario. The recalculation
provided 72 h-EC50 values for growth rate and biomass of 3.55 and 2.02
mg/L, respectively. These values indicate the toxicity of methyl
acrylate to algae is similar to other aquatic species and the
recalculated EC50 values were considered appropriate for the assessment.
In addition, there is
an older study withScenedesmus subspicatus conducted according to
Directive 87/302/EEC, part C.3 without analytical monitoring (BASF AG,
1989). EC50 values after 72 hrs exposure were recalculated and
determined to be 18.3 mg/L (biomass) and 38.1 mg/L (growth rate),
respectively. This study which does not take the possible decrease in
test concentration by volatilisation of the substance into consideration
and is therefore not suitable for the assessment.
In addition, a robust
data set of acute studies is available from the other members of the
acrylic ester category (2-ethylhexyl, ethyl, n-butyl, isobutyl, and
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