Registration Dossier
Registration Dossier
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EC number: 202-500-6 | CAS number: 96-33-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The skin sensitising potential of Methyl acrylate was investigated in a Local Lymphnode Assay conducted according to OECD guideline 429 and GLP regulations (BAMM 2006). The application of the test substance at concentrations of 1, 2.5, 5, 10, or 25 % w/v in acetone:olive oil (4:1) resulted in an increase in isotope incorporation which was greater than 3-fold at the 25 % w/v concentration. Consequently, the test substance was shown to be a potential skin sensitiser. The concentration giving rise to a 3-fold increase in lymphocyte proliferation (EC3) was calculated to be 19.6 % w/v (4900 μg/cm2), indicative of a sensitiser of weak potency.
Methyl acrylate was tested in guinea pigs using a variety of methods and gave a positive response in most of the tests. In the split adjuvant test, Polak test, modified Draize test and modified maximization test, guinea pigs were typically induced with concentrations between 0.2 and 1% (intracutaneously) or 10% (epicutaneously) and challenged with various preparations containing 1-5 % of methyl acrylate (Parker & Turk 1983, Parker et al. 1985, Bull et al. 1985). In addition, the effect of methyl acrylate on the proliferation of auricular lymph nodes after epicutaneous application of the substance on the ear of guinea pigs was investigated (Bull et al. 1985). The authors considerate MA to be a skin sensitiser of medium potency.
For risk assessment purposes and DNEL derivation, the LLNA (BAMM 2006) is the most appropriate study. Based on all the presented data, Methyl acrylate is considered to be a skin sensitizer of weak potency.
Migrated from Short description of key information:
After repeated skin contact with Methyl acrylate sensitization is possible.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
There is no information available to suggest MA is able to produce respiratory sensitisation in animals or humans.
Justification for classification or non-classification
EU classification according to Regulation (EU) No. 1272/2008:
- Skin Sensitization Category 1 B
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