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EC number: 202-500-6
CAS number: 96-33-3
The low and variable recoveries of methyl acrylate in water samples
collected during this test were thought to be due to the volatile nature
of the test substance (vapour pressure 67.5 mm Hg (= 90 hPa) at 20 °C) .
Cummulative mortality and treatment related effects:
Measured Conc. [mg/l]
7AN, 1A, 4C, 1N
AN = appears normal; A = surfacing, C = lethargic, N = lost of
Methyl acrylate is acutely toxic to freshwater and marine fish.LC50 (96 h, flow through) = 3.4 mg/L (measured) (Oncorhynchus mykiss, OECD 203)LC50 (96 h, flow through) = 1.1 mg/L (measured) (Cyprinodon variegatus, OECD 203)As described in section 13.2 of IUCLID, testing information is consistent with six acrylic esters evaluated as a category.
In the key study for
acute toxicity to fish (BAMM, 1995), the 96-hour LC50 for rainbow trout
was 3.4 mg/L based on the mean measured concentrations. This study
followed OECD Guideline 203 using a flow-through design. Nominal
exposure concentrations ranged from 1.3 to 10 mg/L and mean measured
concentrations (0 and 96 hrs) ranged from 0.96 to 6.7 mg/L. After
96-hours of exposure, mortality in the 4.1 and 6.7 mg methyl acrylate/L
treatment groups was 100%. Rainbow trout in the control, 0.96, 1.4 and
2.8 mg methyl acrylate/L treatment groups appeared healthy and normal
throughout the test. The
LC50 was determined based on analytical values.
In a saltwater study
conducted in the sheepshead minnow (BAMM, 1995), the 96-hour LC50 was
estimated to be 1.1 mg/L. This study was conducted according to OECD
Guideline 203 using a flow-through design. Nominal test concentrations
ranged from 1.3 to 10 mg/L, and mean measured concentrations from 0.89
to 7.5 mg/L. The LC50 value was based on analytically determined
concentrations. After 96 hours of exposure, mortality was 100% in all
treatment groups >= 1.6 mg methyl acrylate/L. Mortality in the 0.89 mg
methyl acrylate/L treatment group was 20%.
In addition, a robust
data set of acute studies is available from the other members of the
acrylic ester category (2-ethylhexyl, ethyl, n-butyl, isobutyl, and
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