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Short-term toxicity to fish

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Description of key information

Methyl acrylate is acutely toxic to freshwater and marine fish.
LC50 (96 h, flow through) = 3.4 mg/L (measured) (Oncorhynchus mykiss, OECD 203)
LC50 (96 h, flow through) = 1.1 mg/L (measured) (Cyprinodon variegatus, OECD 203)

Key value for chemical safety assessment

Additional information

In the key study for acute toxicity to fish (BAMM, 1995), the 96-hour LC50 for rainbow trout was 3.4 mg/L based on the mean measured concentrations. This study followed OECD Guideline 203 using a flow-through design. Nominal exposure concentrations ranged from 1.3 to 10 mg/L and mean measured concentrations (0 and 96 hrs) ranged from 0.96 to 6.7 mg/L. After 96-hours of exposure, mortality in the 4.1 and 6.7 mg methyl acrylate/L treatment groups was 100%. Rainbow trout in the control, 0.96, 1.4 and 2.8 mg methyl acrylate/L treatment groups appeared healthy and normal throughout the test. The LC50 was determined based on analytical values.

In a saltwater study conducted in the sheepshead minnow (BAMM, 1995), the 96-hour LC50 was estimated to be 1.1 mg/L. This study was conducted according to OECD Guideline 203 using a flow-through design. Nominal test concentrations ranged from 1.3 to 10 mg/L, and mean measured concentrations from 0.89 to 7.5 mg/L. The LC50 value was based on analytically determined concentrations. After 96 hours of exposure, mortality was 100% in all treatment groups >= 1.6 mg methyl acrylate/L. Mortality in the 0.89 mg methyl acrylate/L treatment group was 20%.

In addition, a robust data set of acute studies is available from the other members of the acrylic ester category (2-ethylhexyl, ethyl, n-butyl, isobutyl, and tert-butyl acrylate).