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Short-term toxicity to aquatic invertebrates

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Description of key information

Methyl acrylate is acutely toxic to freshwater and saltwater invertebrates.
EC50 (48 h) = 2.6 mg/L (measured), (Daphnia magna, OECD TG 202, flow through)
LC50 (96 h) = 1.6 mg/L (measured), (Mysidopsis bahia, EPA OTS 797.1930, flow through)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
2.6 mg/L

Marine water invertebrates

Marine water invertebrates
Effect concentration:
1.6 mg/L

Additional information

An acute toxicity study with Daphnia magna (BAMM, 1995) indicated the 48-hour EC50 was 2.6 mg/L based on mean measured concentrations. This study followed OECD TG 202, part I using a flow-through design. Nominal exposure concentrations ranged from 1.3 to 10 mg/L and mean measured concentrations ranged from 0.88 to 6.4 mg/L. Complete immobilization occurred in the two highest concentrations (4.1 and 6.4 mg/L, measured). The NOEC was 0.88 mg/L (measured).

In a second toxicity study with the seawater invertebrate Mysidopsis bahia (BAMM, 1996) an 96-hr LC50 of 1.6 mg/L based on mean measured concentrations was determined. This study was conducted according to the procedures in Title 40 of the Code of Federal Regulations, Part 797, Section 1930, Mysid Shrimp Acute Toxicity Test, using a flow-through design. Nominal exposure concentrations ranged from 1.2 to 9 mg/L and mean measured concentrations ranged from 0.4 to 3.1/L. After 96 hours of exposure, mortality in the 0.66, 1.7 and 3.1 mg methyl acrylate/L was 5, 55 and 100 %, respectively. Mysids in the negative control, 0.40 and 0.99 mg methyl acrylate/L treatment groups appeared healthy and normal throughout the test. Thus, the NOEC was considered to be 0.99 mg/L (measured).

In a short-term test with Daphnia magna conducted according to EEC guideline a 48-hour EC50 of 2.21 mg/L was found (BASF AG, 1989). The given effect value was related to nominal concentrations.

Since MA is readily biodegradable and undergoes slow hydrolysis in water, only test results from studies with analytical monitoring were used for the hazard assessment for freshwater and saltwater invertebrates.

In addition, a robust data set of acute studies is available from the other members of the acrylic ester category (2-ethylhexyl, ethyl, n-butyl, isobutyl, and tert-butyl acrylate).