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EC number: 202-500-6
CAS number: 96-33-3
Methyl acrylate is acutely toxic to freshwater and saltwater invertebrates.EC50 (48 h) = 2.6 mg/L (measured), (Daphnia magna, OECD TG 202, flow through)LC50 (96 h) = 1.6 mg/L (measured), (Mysidopsis bahia, EPA OTS 797.1930, flow through)
An acute toxicity
study with Daphnia magna (BAMM, 1995) indicated the 48-hour EC50 was 2.6
mg/L based on mean measured concentrations. This study followed OECD TG
202, part I using a flow-through design. Nominal exposure concentrations
ranged from 1.3 to 10 mg/L and mean measured concentrations ranged from
0.88 to 6.4 mg/L. Complete immobilization occurred in the two highest
concentrations (4.1 and 6.4 mg/L, measured). The NOEC was 0.88 mg/L
In a second toxicity
study with the seawater invertebrate Mysidopsis bahia (BAMM, 1996) an
96-hr LC50 of 1.6 mg/L based on mean measured concentrations was
determined. This study was conducted according to the procedures in
Title 40 of the Code of Federal Regulations, Part 797, Section 1930,
Mysid Shrimp Acute Toxicity Test, using a flow-through design. Nominal
exposure concentrations ranged from 1.2 to 9 mg/L and mean measured
concentrations ranged from 0.4 to 3.1/L. After
96 hours of exposure, mortality in the 0.66, 1.7 and 3.1 mg methyl
acrylate/L was 5, 55 and 100 %, respectively. Mysids in the negative
control, 0.40 and 0.99 mg methyl acrylate/L treatment groups appeared
healthy and normal throughout the test. Thus, the NOEC was considered to
be 0.99 mg/L (measured).
In a short-term test
with Daphnia magna conducted according to EEC guideline a 48-hour EC50
of 2.21 mg/L was found (BASF AG, 1989). The given effect value was
related to nominal concentrations.
Since MA is readily
biodegradable and undergoes slow hydrolysis in water, only test results
from studies with analytical monitoring were used for the hazard
assessment for freshwater and saltwater invertebrates.
In addition, a robust
data set of acute studies is available from the other members of the
acrylic ester category (2-ethylhexyl, ethyl, n-butyl, isobutyl, and
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