Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-500-6 | CAS number: 96-33-3
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary quotation
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- Suvorov AP
- Year:
- 1 971
- Bibliographic source:
- Farmakol. Toksikol. 34: 593-594
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Suvorov AP
- Year:
- 1 971
- Bibliographic source:
- Farmakol. Toksikol. 34: 593-594, 1971; cited in: Review Methylacrylat, Dr. Zeller, (1986)
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Suvorov AP
- Year:
- 1 971
- Bibliographic source:
- Farmakol. Toksikol. 34: 593-594, 1971; cited in MAK Begruendung Methacrylat (1985) (in German)
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl acrylate
- EC Number:
- 202-500-6
- EC Name:
- Methyl acrylate
- Cas Number:
- 96-33-3
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methyl prop-2-enoate
- Details on test material:
- Methyl acrylate, not further specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Route of Administration: dermal
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 24 hours
- Frequency of treatment:
- twice within 24 hours; 5 hours per application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mL of the undiluted test substance
Basis:
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: 30 days
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Methyl acrylate applied to rabbit skin twice within a 24
hours interval caused decreased blood ascorbic acid and
reduced glutatione levels. Local necrotic changes were
observed. All effects were reversible within 30 days.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
