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EC number: 202-500-6 | CAS number: 96-33-3
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary quotation
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- Suvorov AP
- Year:
- 1 971
- Bibliographic source:
- Farmakol. Toksikol. 34: 593-594
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Suvorov AP
- Year:
- 1 971
- Bibliographic source:
- Farmakol. Toksikol. 34: 593-594, 1971; cited in: Review Methylacrylat, Dr. Zeller, (1986)
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Suvorov AP
- Year:
- 1 971
- Bibliographic source:
- Farmakol. Toksikol. 34: 593-594, 1971; cited in MAK Begruendung Methacrylat (1985) (in German)
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl acrylate
- EC Number:
- 202-500-6
- EC Name:
- Methyl acrylate
- Cas Number:
- 96-33-3
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methyl prop-2-enoate
- Details on test material:
- Methyl acrylate, not further specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Route of Administration: dermal
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 24 hours
- Frequency of treatment:
- twice within 24 hours; 5 hours per application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mL of the undiluted test substance
Basis:
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: 30 days
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Methyl acrylate applied to rabbit skin twice within a 24
hours interval caused decreased blood ascorbic acid and
reduced glutatione levels. Local necrotic changes were
observed. All effects were reversible within 30 days.
Applicant's summary and conclusion
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