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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary quotation

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
Suvorov AP
Year:
1971
Bibliographic source:
Farmakol. Toksikol. 34: 593-594
Reference Type:
secondary source
Title:
No information
Author:
Suvorov AP
Year:
1971
Bibliographic source:
Farmakol. Toksikol. 34: 593-594, 1971; cited in: Review Methylacrylat, Dr. Zeller, (1986)
Reference Type:
secondary source
Title:
No information
Author:
Suvorov AP
Year:
1971
Bibliographic source:
Farmakol. Toksikol. 34: 593-594, 1971; cited in MAK Begruendung Methacrylat (1985) (in German)

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl acrylate
EC Number:
202-500-6
EC Name:
Methyl acrylate
Cas Number:
96-33-3
Molecular formula:
C4H6O2
IUPAC Name:
methyl acrylate
Details on test material:
Methyl acrylate, not further specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on exposure:
Route of Administration: dermal
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
24 hours
Frequency of treatment:
twice within 24 hours; 5 hours per application
Doses / concentrations
Remarks:
Doses / Concentrations:
1 mL of the undiluted test substance
Basis:

Control animals:
not specified
Details on study design:
Post-exposure period: 30 days

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Methyl acrylate applied to rabbit skin twice within a 24
hours interval caused decreased blood ascorbic acid and
reduced glutatione levels. Local necrotic changes were
observed. All effects were reversible within 30 days.

Applicant's summary and conclusion