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Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1930
Report date:
1930

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl acrylate
EC Number:
202-500-6
EC Name:
Methyl acrylate
Cas Number:
96-33-3
Molecular formula:
C4H6O2
IUPAC Name:
methyl acrylate
Details on test material:
methyl acrylate, not further specified

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Duration of treatment / exposure:
up to 5 injections / week
Doses / concentrations
Remarks:
Doses / Concentrations:
50; 100; 200; 300; 400; 500 mg/kg bw; in an "oily solution"
No. of animals per sex per dose:
50 - 400 mg/kg bw: 1 animal per dose
500 mg/kg bw: 2 animals
Control animals:
no
Details on study design:
Post-exposure period: not specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Mortality and clinical signs:
500 mg/kg: lethal for 2 animals after the first injection
(time to death: 4 hours to 1 day), clinical signs:
convulsions, irregular breathing, lateral position.
400 mg/kg: lethal after second injection; no specific
clinical signs after first injection (hyperactivity),
convulsions after 2nd injection.
300 mg/kg (2 injections): no mortality, no clinical signs
200 mg/kg (3 injections): no mortality, no clinical signs
100 mg/kg (5 injections): no mortality, no clinical signs
50 mg/kg (5 injections): no mortality, no clinical signs

Applicant's summary and conclusion