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EC number: 202-500-6
CAS number: 96-33-3
A testing proposal is submitted for long-term toxicity to fish testing of Methyl acrylate (EC Number: 202-500-6, CAS Number: 96-33-3). In addition of being used for the substance itself, the testing proposal will also be applied in support of read-across for the Lower Alkyl Acrylates category members (except Acrylic acid).
The use of methyl acrylate as a monomer, almost exclusively in closed systems for the production of copolymers with other monomers such as acrylic acid and its salts, amides, esters, methacrylates, acrylonitrile etc., indicates that environmental exposure would be limited. The volatility of methyl acrylate provides for volatilization of any releases to the air. Methyl acrylate is readily biodegradable, has low potential for bioaccumulation, and is slowly photodegradable. Accidental releases to the environment would not result in accumulation or persistence. The relatively high water solubility and corresponding low log Kow indicate that no bioaccumulation potential exists.
Acute effects levels were in the same range of concentrations for all three trophic levels, i.e. between 1 and 10 mg/L. In order to assess long-term toxicity towards aquatic organisms, 21-day chronic life-cycle studies with Daphnia magna were conducted with the structurally related n-butyl acrylate (NOEC reproduction 0.136 mg/L, OECD 211, semi-static); ethyl acrylate (NOEC reproduction 0.19 mg/L, EPA OTS 797.1330, flow-through); and 2-Ethylhexyl acrylate (EC10 reproduction 0.85 mg/L TWM, OECD 211, semi-static). For Methyl acrylate, the long-term aquatic invertebrate endpoint was filled by read-across from the NOEC of 0.136 mg/L. Considering the results and the application of a relevant assessment factor, no risks were observed (PEC/PNEC<1).
Therefore the long-term fish testing has been waived so far. Still, long-term toxicity testing on fish (preferably the ELS study) is a standard information requirement according to REACH Annex IX 9.1.6. The recently proposed REACH amendments indicate that this endpoint is not subject to Column 2 adaptation. A testing proposal has been submitted for long-term toxicity to fish testing of Methyl acrylate (EC Number: 202-500-6, CAS Number: 96-33-3). In addition of being used for the substance itself, the testing proposal will also be applied in support of read-across for the Lower Alkyl Acrylates category members (except Acrylic acid).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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