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EC number: 202-500-6
CAS number: 96-33-3
Skin contact with methyl acrylate causes irritation.
Methyl acrylate may be irritating to the respiratory system, and may
cause serious irritation to the eyes.
methyl acrylate was highly irritating to the skin of rabbits, when
applied for 1 or 4 hours under semiocclusive conditions. After 1-
and 4-hours exposures, slight to well-defined erythema (grades 1 and
2 of the Draize scoring system) and slight edema (grade 1) were
still present in some animals at the end of the observation period at
day 7. 4 of 6 animals showed scaling or severe scaling at the end of the
observation period. Mean erythema and edema scores (24-72 hours)
were 2.17 and 2.44, respectively, after 4-hour exposure. Erythema and
edema were most severe at 1 hour postexposure (grades 2 and 3) and
slowly decreased in intensity during the following days. One animal (out
of 6 tested) showed superficial necrosis after exposure for 1 hour (BASF
test was repeated under occlusive conditions, i.e. over-predictive
conditions, with more severe results (BASF AG 1982). Mean scores for
erythema and edema (24-72 hours) were 3.56 and 3.72, respectively. At
the end of the 7-day observation period, 2 of 6 animals showed a full
thickness necrosis, the other 4 animals showed superficial necrosis.
other tests, all under occlusive conditions, confirmed the presented
results (BASF AG 1978, BASF AG 1979, Potokar et al. 1985).
acrylate proved to be highly irritating to the skin of rabbits, when
applied for 4 hrs using semi-occlusive conditions in a study similar to
OECD TG 404. No full-thickness skin destruction was observed under these
conditions which are relevant for classification according to 67/548/EEC
and GHS (EU and UN), respectively. Thus, methyl acrylate was assessed to
be irritating to the skin.
on the eye irritation potential of methyl acrylate is based upon the
weight of evidence from available studies.
methyl acrylate (0.1 mL) was instilled into the eye of one rabbit and
caused corneal damage, slight iritis and severe lesions of the
conjunctivae. After 7 days the cornea showed moderate to severe opacity
with no details of the iris visible. In addition, slight iritis and
moderate to severe lesions of the conjunctivae were noticeable. Mean
scores for cornea, iris, conjunctivae and chemosis (24-72 hours) were
2.33, 1, 2, and 3, respectively (BASF AG 1978). The
authors considered methyl acrylate as severely irritating to the eyes,
results do not fulfill the CLP requirements for a Cat 1 as a stand-alone
study since the observation period was only 7 days and the corneal
opacity and iritis scores did not support a cat 1 classification. Specifically:
study was conducted on 1 rabbit and the observation period was 7 days,
not 21 as indicated as the “normal” period of observation. If the study
were carried out to 21 days of observation it is expected that full
reversal of irritation would occur based upon the below additional
category 1 classification is not supported.
study was conducted on only 1 rabbit, not 3. Also, the mean 24, 48 and
72 hr scores for corneal opacity and iritis were 2.33 and 1
respectively. These scores also do not support a category 1
weight of evidence that supports an eye irritation Category 2
classification for methyl acrylate includes a recently finalized Bovine
Corneal Opacity and Permeability Test (BCOP) study (Reliability 1) that
is compliant with OECD 437 (BAMM, 2017). This
study showed conclusively that methyl acrylate was not corrosive. According
to the EURL ECVAM DB-ALM Protocol 127 Classification, the substance
would be considered a Mild Eye Irritant.
Older rabbit eye
irritation studies using undiluted methyl acrylate are also available
that support classification of this substance a Cat 2 eye irritant as
with these studies showing reversibility of the irritation within 7 days
Upon assessment of TNO,
1978 against the GHS criteria and consideration of all available eye
irritation study information the weight of evidence indicates that
Methyl acrylate should be classified as a Cat 2 eye irritant.
on the presented data, methyl acrylate may cause serious eye irritation.
exists no standard test method for the assessment of respiratory
irritation. Thus, the labelling of MA with "R 37, Irritating to
respiratory tract" according to current EU regulations is not based on
results of a specific respiratory irritation test, but on considerations
on the general irritation potential of MA. There is evidence that methyl
acrylate vapours were irritating to the eyes and respiratory tract of
rats and mice (BASF AG 1979). In addition, Silver et al. (1981)
confirmed the respiratory irritancy of methyl acrylate by measuring its
effect on the respiratory frequency, tidal volume, minute ventilation,
and rectal temperature as indices for irritancy.
labelling with R 37 is confirmed on the basis of all of the respective
data mentioned in this IUCLID5 -Registration Dossier.
EU classification according to Annex I of Directive 67/548/EEC: Xi,
GHS classification (GHS UN rev.3, 2009):
- Skin corrosion/irritation: Category 2
- Serious eye damage/eye irritation: Category 1
- Specific target organ toxicity, Single exposure: Category 3 (May cause
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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