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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study acceptable for assessment (short summary report available)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Further experience with the range finding test in the industrial toxicology laboratory.
Author:
Smyth HF and Carpenter CP
Year:
1948
Bibliographic source:
J. Ind. Hyg. Tox. 30: 63-68
Reference Type:
secondary source
Title:
Further experience with the range finding test in the industrial toxicology laboratory
Author:
Smyth H.F. und Carpenter C.P.
Year:
1948
Bibliographic source:
J. Ind. Hyg. Tox., 30, 63-68; cited in MAK Begruendung Methylacrylat (1985) (in German)

Materials and methods

Principles of method if other than guideline:
Acute dermal toxicity study in rabbits conducted according to the method described by Draize et al. (1944).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl acrylate
EC Number:
202-500-6
EC Name:
Methyl acrylate
Cas Number:
96-33-3
Molecular formula:
C4H6O2
IUPAC Name:
methyl acrylate
Details on test material:
- Name of test material (as cited in study report): Methyl acrylate
- Analytical purity: no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: MethyI "Cellosolve" solvent
Details on dermal exposure:
TEST SITE
- Type of wrap if used: rubber cuff application
Duration of exposure:
24 h
Doses:
no data
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 250 mg/kg bw
Remarks on result:
other: original data: LD50 = 1.3 mL/kg; calculated with a density of 0.96 g/mL
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU