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EC number: 203-628-5 | CAS number: 108-90-7
ORALThe LD50(oral, rat) was greater than 2000 mg/kg body weight in a study performed according to OECD guideline 401 with acceptable restrictions. Hyperpnea was as well frequently observed in all exposed rats shortly after administration. The following intoxication symptoms have been observed: transient ataxia, laboured breathing and prostration in a dose-related manner at the two higher doses.INHALATION:The Inhalation Hazard Test was performed to determine the hazard of volatile substances in general and chlorobenzene in particular (Klimisch H.J., 1988, Arch. Toxicol. 61, 411 - 416).Glass flask generator was used for the generation of a vapor saturated inhalation atmosphere. The exposure system used was made of two simple glass systems with tubes for the exposure of six to ten animals. 3 male and 3 female rats have been exposed to 66 mg/L (nominal concentration) and LT0 (time T after which no animals died within 14 days of post-exposure observation period) and LT50 (time of exposure after which 50% of the animals died within 14 days of the post-exposure observation period) were calculated.LT0 was estimated to be 0.17 h. LT 50 value was calculated from IHT results. LT50=1.8 h.The LC50 was calculated by the applicant according to the Haber´s rule: LC50= 66 mg/L * (1.8h/4h)= 29.7 mg/L.DERMAL:According to REACh Annex VIII column 2, a dermal study does not need to be conducted since due to the physico-chemical parameters, exposure by inhalation is likely.
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