Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Title:
No information
Author:
Yadav JS & Seth N (2001). Cytogenetical damage in petrol pump workers. IHHG 1(2):145-150.

Materials and methods

Type of study / information:
Cytogenetic study
Endpoint addressed:
genetic toxicity
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Cytogenetic studies were carried out on 37 petrol pump workers exposed to chlorobenzene and 36 control individuals with no known exposure at work.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results:
The mean mitotic index in exposed workers (7.86) was found significantly higher than in controls (4.60). Cromosomal aberration were observed to be elevated in exposed group . Frequency of Syster Chomatide Exchange in exposed workers (6.49) was significantly higher than controls (5.62). Exposed group showed about two fold increase in the frequency of satellite associations (13.4) as compared with controls (7.91).

Any other information on results incl. tables

It may be concluded that the petrol pump workers are at risk to cytogenetic demage at their work places.

Applicant's summary and conclusion