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EC number: 203-628-5 | CAS number: 108-90-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1992/93
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Average chlorobenzene concentration and air concentrations of benzene, chloroform, methanol and toluene were also given.
Data source
Reference
- Title:
- No information
- Author:
- Major J et al (1992). Acta Medica Hungarica, 49:79-90.
Materials and methods
- Study type:
- other: study on workers exposed to chlorobenzen air concentrations of benzene, chloroform, methanol and toluene
- Endpoint addressed:
- genetic toxicity
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD guideline 476
- Deviations:
- yes
- Remarks:
- Test performed on human lymphocytes. No postive control used
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Chlorobenzene
- EC Number:
- 203-628-5
- EC Name:
- Chlorobenzene
- Cas Number:
- 108-90-7
- Molecular formula:
- C6H5Cl
- IUPAC Name:
- chlorobenzene
- Details on test material:
- Average chlorobenzene concentration was 33.5 +- 17.77 mg/m3 air (range 1.9 - 173.4 mg/m3 air), air concentrations of benzene, chloroform, methanol and toluene were also given.
Constituent 1
Method
- Subjects:
- workers
- Ethical approval:
- not specified
- Route of exposure:
- inhalation
- Reason of exposure:
- other: exposure at workplace
- Exposure assessment:
- estimated
- Details on exposure:
- exposure at workplace:Average chlorobenzene concentration was 33.5 +- 17.77 mg/m3 air (range 1.9 - 173.4 mg/m3 air), air concentrations of benzene, chloroform, methanol and toluene were also given.
Results and discussion
- Clinical signs:
- No data
Any other information on results incl. tables
Chronic effects:
A possible genotoxic effect was assessed in workers
manufacturing the pesticide Lutidin of monochlorinated
benzene. Average chlorobenzene concentration was 33.5 +-
17.77 mg/m3 air (range 1.9 - 173.4 mg/m3 air), air
concentrations of benzene, chloroform, methanol and toluene
were also given. The urinary phenol concentration of exposed
workers was 602.3 +- 89.3 mg/l (n = 18). Peripheral blood
lymphocytes were obtained from 147 exposed workers, 33
industrial control workers and 60 historical controls and
assessed for mutations in the hypoxanthine - (guanine) -
phosphoribosyl transferase (HGPRT) locus of the X chromosome
by measuring the 6-thioguanine (6-TG) resistance and for DNA
repair capacity by measuring the unscheduled DNA synthesis
after 250 nm UV light irradiation. Mutation frequencies were
increased among workers exposed to monochlorinated benzene
in correlation with the duration of work time, compared to
the controls. Mutation frequencies were lower than expected
among non-smoking, long exposed workers (> 10 years).
Smoking itself proved to be an effective confounding factor
in the enhancement of point mutations in the case of
long-exposed workers. DNA repair capacity of exposed workers
was not significantly increased compared to industrial
control.
(Hungary; published 1992/93)
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