Registration Dossier

Environmental fate & pathways

Monitoring data

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Administrative data

Endpoint:
monitoring data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scietifically accpetable publication, basic data given.

Data source

Reference
Reference Type:
publication
Title:
Biological monitoring of exposure to monochlorobenzene
Author:
KustersE. and Lauwerys R.
Year:
1990
Bibliographic source:
Int. Arch. Occup. Environ. Health 62: 329-331

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
The concentration of the substance was determined with HPLC.
GLP compliance:
no
Media:
air

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Concentrationopen allclose all
Country:
not specified
Location:
concentration at contaminated site (industry)
Substance or metabolite:
substance
Conc.:
1.2 ppm
Country:
not specified
Location:
industry workers
Substance or metabolite:
metabolite
Remarks:
4-chlorophenol in urine
Conc.:
1.4 other: mg/g
Country:
not specified
Location:
industry workers
Substance or metabolite:
metabolite
Remarks:
4- chlorocatechol in urine
Conc.:
3.3 other: mg/g

Any other information on results incl. tables

 

Results

 

Environmental Monitoring

    

Biological monitoring

   

Monochlorobenzene in air (ppm)

 

4-chlorophenol in urine (mg/g create)

 

4- chlorocatechol in urine (mg/g create)

 

Median

 

1.2

 

1.4

 

3.3

 

Range

  < 0.05 - 106  < 0.2 ¿ 21.1  < 0.2 ¿ 57.9

The followed up of 21 workers during several consecutiv edays showed that more than 80 % of the metabolites excreted in urine are eliminated within 16 hours after the end of exposurean dno tendency for increased concentrations of the metabolites in the preshift urine samples during the workweek could be proven.

Applicant's summary and conclusion