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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1976
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Peer-reviewed (EPA HPV SIDS)

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
One female rabbit was dosed with 5,010 mg/kg bw and 2 males with 7,940 mg/kg bw of the test substance. The animals were observed over 14d.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Chlorobenzene
EC Number:
203-628-5
EC Name:
Chlorobenzene
Cas Number:
108-90-7
Molecular formula:
C6H5Cl
IUPAC Name:
chlorobenzene
Details on test material:
Purity: no data

Test animals

Species:
rabbit
Strain:
other: New Zealand white
Sex:
male/female
Details on test animals or test system and environmental conditions:
Average weight at study initiation:
male: 2.1 kg
female: 1.8 kg

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
male : 7940 mg/kg bw
female: 5010 mg/kg bw
No. of animals per sex per dose:
2 males: 7940 mg/kg bw
1 female: 5010 mg/kg bw:
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
> 5 010 mg/kg bw
Sex:
male
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Mortality:
No deaths occured.

Applicant's summary and conclusion