Registration Dossier
Registration Dossier
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EC number: 203-628-5 | CAS number: 108-90-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Peer-reviewed (EPA HPV SIDS)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- One female rabbit was dosed with 5,010 mg/kg bw and 2 males with 7,940 mg/kg bw of the test substance. The animals were observed over 14d.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Chlorobenzene
- EC Number:
- 203-628-5
- EC Name:
- Chlorobenzene
- Cas Number:
- 108-90-7
- Molecular formula:
- C6H5Cl
- IUPAC Name:
- chlorobenzene
- Details on test material:
- Purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand white
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Average weight at study initiation:
male: 2.1 kg
female: 1.8 kg
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- male : 7940 mg/kg bw
female: 5010 mg/kg bw - No. of animals per sex per dose:
- 2 males: 7940 mg/kg bw
1 female: 5010 mg/kg bw: - Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Mortality:
- No deaths occured.
Applicant's summary and conclusion
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