Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1976
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Peer-reviewed (EPA HPV SIDS)

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
One female rabbit was dosed with 5,010 mg/kg bw and 2 males with 7,940 mg/kg bw of the test substance. The animals were observed over 14d.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Chlorobenzene
EC Number:
203-628-5
EC Name:
Chlorobenzene
Cas Number:
108-90-7
Molecular formula:
C6H5Cl
IUPAC Name:
chlorobenzene
Details on test material:
Purity: no data

Test animals

Species:
rabbit
Strain:
other: New Zealand white
Sex:
male/female
Details on test animals or test system and environmental conditions:
Average weight at study initiation:
male: 2.1 kg
female: 1.8 kg

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
male : 7940 mg/kg bw
female: 5010 mg/kg bw
No. of animals per sex per dose:
2 males: 7940 mg/kg bw
1 female: 5010 mg/kg bw:
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
> 5 010 mg/kg bw
Sex:
male
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Mortality:
No deaths occured.

Applicant's summary and conclusion