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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication/study report which meets basic scientific principles

Data source

Reference
Title:
No information
Author:
Smith, M.A., Gandy, J. (1990): Air Force Office of|Scientific Research report No. 90 0684, NTIS/AD-7224022

Materials and methods

Type of study / information:
Type: other: Acute toxicity
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Single intraperitoneal administration of different concentrations of chlorobenzene (0.01 - 1.0 mL/kg bw ) to male mice  in order to evaluate the effect
on the concentration of hepatic glutathione.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Chlorobenzene
EC Number:
203-628-5
EC Name:
Chlorobenzene
Cas Number:
108-90-7
Molecular formula:
C6H5Cl
IUPAC Name:
chlorobenzene
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): chlorobenzene
- Analytical purity: No data

Results and discussion

Any other information on results incl. tables

After a single i.p. administration of 0.01 - 1.0 ml chloro-
benzene/kg bw (11 - 1106 mg/kg bw) to male B6C3F1 mice the
hepatic glutathione concentration was significantly
decreased at doses >= 0.1 ml/kg at 3 h post-treatment and the
serum alanine aminotransferase activity was significantly
increased at doses >= 0.5 ml/kg at 48 h posttreatment. A
dose of 1.0 ml/kg was lethal.

Applicant's summary and conclusion