Registration Dossier
Registration Dossier
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EC number: 203-628-5 | CAS number: 108-90-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication/study report which meets basic scientific principles
Data source
Reference
- Title:
- No information
- Author:
- Smith, M.A., Gandy, J. (1990): Air Force Office of|Scientific Research report No. 90 0684, NTIS/AD-7224022
Materials and methods
- Type of study / information:
- Type: other: Acute toxicity
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Single intraperitoneal administration of different concentrations of chlorobenzene (0.01 - 1.0 mL/kg bw ) to male mice in order to evaluate the effect
on the concentration of hepatic glutathione. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Chlorobenzene
- EC Number:
- 203-628-5
- EC Name:
- Chlorobenzene
- Cas Number:
- 108-90-7
- Molecular formula:
- C6H5Cl
- IUPAC Name:
- chlorobenzene
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): chlorobenzene
- Analytical purity: No data
Constituent 1
Results and discussion
Any other information on results incl. tables
After a single i.p. administration of 0.01 - 1.0 ml chloro-
benzene/kg bw (11 - 1106 mg/kg bw) to male B6C3F1 mice the
hepatic glutathione concentration was significantly
decreased at doses >= 0.1 ml/kg at 3 h post-treatment and the
serum alanine aminotransferase activity was significantly
increased at doses >= 0.5 ml/kg at 48 h posttreatment. A
dose of 1.0 ml/kg was lethal.
Applicant's summary and conclusion
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