Registration Dossier
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EC number: 203-628-5 | CAS number: 108-90-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Adopted according to BUA report (public available peer reviewed source)
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Public available peer reviewed source. In order to determine the octanol-water coefficient the calculation/correlation methods (indirect methods) have been used.
- GLP compliance:
- not specified
- Type of method:
- other: calculation/correlation methods
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- ca. 2.855
- Remarks on result:
- other: Temp expected ca 20-25°C, and pH unspecified.
- Type:
- log Pow
- Partition coefficient:
- ca. 2.81
- Remarks on result:
- other: Temp expected ca 20-25°C, and pH unspecified.
- Type:
- log Pow
- Partition coefficient:
- ca. 2.83
- Remarks on result:
- other: Temp expected ca 20-25°C, and pH unspecified.
- Type:
- log Pow
- Partition coefficient:
- ca. 2.84
- Remarks on result:
- other: Temp expected ca 20-25°C, and pH unspecified.
- Type:
- log Pow
- Partition coefficient:
- ca. 2.86
- Remarks on result:
- other: Temp expected ca 20-25°C, and pH unspecified.
- Type:
- log Pow
- Partition coefficient:
- ca. 2.8
- Remarks on result:
- other: Temp expected ca 20-25°C, and pH unspecified.
- Type:
- log Pow
- Partition coefficient:
- ca. 2.46
- Remarks on result:
- other: Temp expected ca 20-25°C, and pH unspecified.
- Executive summary:
BUA report 54, 1990
Chlorobenzene n-Octanol/water partition coefficients , log Pow are listed below:
-calculated according to Leo 2.855
-calculated according to Rekker 2.81
-calculated according to Nys & Rekker 2.83
-calculated (THOR database) 2.84
-calculated according to Leo 2.86
- calculated according to Leathy 2.80
- shaking method 2.84
-shaking method 2.46
-shaking method at 20°C 2.84
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Adopted according to BUA report (public available peer reviewed source)
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Public available peer reviewed source. In order to determine octanol-water partition coefficient, experimental methods (direct methods: shaking, column chromatographic method and HPLC, slow stirring method) have been used.
- GLP compliance:
- not specified
- Type of method:
- other: direct methods: shaking, column chromatographic method and HPLC, slow stirring method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- ca. 2.98
- Temp.:
- 25 °C
- Remarks on result:
- other: pH unspecified.
- Type:
- log Pow
- Partition coefficient:
- ca. 3
- Remarks on result:
- other: Temp expected ca 20-25°C, and pH unspecified.
- Type:
- log Pow
- Partition coefficient:
- ca. 2.898
- Remarks on result:
- other: Temp expected ca 20-25°C, and pH unspecified.
- Type:
- log Pow
- Partition coefficient:
- ca. 3.79
- Remarks on result:
- other: Temp expected ca 20-25°C, and pH unspecified.
- Executive summary:
BUA report 54, 1990, part 2
Chlorobenzene n-Octanol/water partition coefficients , log Pow are listed below:
-column chromatographic method
and HPLC (25°C) 2.98 +-0.02
-RP-HPLC method (25°C) 2.98 +-0.04
- RP-HPLC method 3.00
- slow stirring method 2.898 +-0.004
-method not given 3.79
Referenceopen allclose all
Temperature and pH not reported
Chlorobenzene n-Octanol/water partition coefficients , log Pow are listed below:
-calculated according to Leo 2.855
-calculated according to Rekker 2.81
-calculated according to Nys & Rekker 2.83
-calculated (THOR database) 2.84
-calculated according to Leo 2.86
- calculated according to Leathy 2.80
- shaking method 2.84
-shaking method 2.46
-shaking method at 20°C 2.84
Chlorobenzene n-Octanol/water partition coefficients , log Pow are listed below:
-column chromatographic method and HPLC (25°C) 2.98 +-0.02
-RP-HPLC method (25°C) 2.98 +-0.04
- RP-HPLC method 3.00
- slow stirring method 2.898 +-0.004
-method not given 3.79
Description of key information
According to literature (BUA report, 1990; secondary source),
Chlorobenzene n-Octanol/water partition coefficients , log Pow are listed below:
- calculated according to Leo 2.855
- calculated according to Rekker 2.81
- calculated according to Nys & Rekker 2.83
- calculated (THOR database) 2.84
- calculated according to Leo 2.86
- calculated according to Leathy 2.80
- shaking method 2.84
- shaking method 2.46
- shaking method at 20°C 2.84
- column chromatographic method and HPLC (25°C) 2.98 +-0.02
- RP-HPLC method (25°C) 2.98 +-0.04
- RP-HPLC method 3.00
- slow stirring method 2.898 +-0.004
- method not given 3.79
The substance has LOW potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4 ).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3
- at the temperature of:
- 20 °C
Additional information
Several literature sources were available and provide partition coefficient values for the substance, ranging between 2,18 and 3,79; temperature, when provided is ca 20-25°C, pH is not specified in any source. The BUA report, considered as a reliable source and gathering most of sources, with both indirect (calculation) and direct methods, was chosen as key study. The worst-case value of 3,00 (discarding the unknown method data) is retained as key value.
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