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EC number: 203-149-1
CAS number: 103-83-3
RS-Freetext:Mortality:at 400 mg/kg bw 4/5 males and 5/5 females died within the treatment period. Cause of deaths could not be determined.Clinical signs:100 mg/kg: m+f: miosis200 mg/kg: m+f: miosis, salivation; reversible during recovery400 mg/kg: m+f: miosis, salivation, dirty hair f: premortal tremors m: reduced weight gain: ~20% after 4 weeks; partial recovery after end of treatmentFood consumption:no effectsHematology:400 mg/kg: reduced white cell number (the 1 surviving male)Clinical chemistry:200 mg/kg: increased total cholesterolUrinalysis:100 mg/kg: increased urine volume (m)200 mg/kg: increased urine volume (m+f)400 mg/kg: increased urine volume (m)Organ weights:200 mg/kg: increased absolute weight (spleen, m; liver, f) increased relative weight (liver, f) after recovery: increased absolute weight (adrenals, m, slight) increased relative weight (adrenals, m, slight)400 mg/kg: decreased absolute weight (spleen, m)Histopathology:Survivors: no effectsDeceased animals: inclusion bodies in hepatocytes (m+f); degeneration of adrenal cortex (f);
N,N-Dimethylbezylamine was given by gavage to male and female Crj:CD (SD) rats in doses of 0 (corn oil), 50, 100, 200, 400 mg/kg bw/day diluted in corn oil over a period of 28 days. In addition, animals of the control group and animals treated with 200 and 400 mg/kg bw/day were obseserved after termination of treatment for further 2 weeks (recovery group). Mortalities of both males and females receiving 400 mg/kg were observed from week 2. Clinical observation revealed miosis in both sexes receiving 100 mg/kg and miosis and salivation in those receiving 200 and 400 mg/kg. Body weight gain was suppressed in males receiving 400 mg/kg. Slight increases in total cholesterol were observed in males receiving 200 mg/kg. Pathological examination revealed no abnormalities attributable to the test substance treatment. The NOEL for repeat dose toxicity is considered to be 50 mg/kg/day for both sexes (MHLW 1997).
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