Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-149-1 | CAS number: 103-83-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02/07/83 - 11/02/83
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- no details on dissolved oxygen concentrations
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- age: 29 days
mean length: 22.3 mm
SD length: 1.372 mm
mean weight: 0.155 g
SD weight: 0.0268 g
loading: 1.550 g/L - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 36.5 mg/L CaCO3 (3.85)
- Test temperature:
- 25.4 °C (0.32)
- pH:
- 7.61 (0.10)
- Dissolved oxygen:
- 6.6 (mg/L) (0.33)
- Nominal and measured concentrations:
- Nominal concentrations: 14.2 mg/L, 21.8 mg/L, 33.6 mg/L, 51.7 mg/L and 79.5 mg/L
Average concentrations: 15.7 mg/L, 22 mg/L, 30.6 mg/L, 46.6 mg/L and 67.6 mg/L - Details on test conditions:
- alkalinity: 40 mg/L CaCO3 (0.71)
tank volume: 2.0 L
toxicant stock: 2200 mg/L diluted (blended) - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 37.8 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Affected fish lost schooling behavior, swam near the tank surface, and were overreactive to external stimuli. Equilibrium loss was not observed prior to death. Effect data were not reccorded. The pH of the stock solution was adjusted to that of lake water with HCl.
Table of mortalities number:
Hours Control A: 14.2 mg/L B: 21.8 mg/L C: 33.6 mg/L D: 51.7 mg/L E: 79.5 mg/L 24 0 0 0 1 20 20 48 0 0 0 1 19 20 72
0 0 0 1 19 20 96
0 0 0 1 19 20 - Validity criteria fulfilled:
- yes
- Remarks:
- mortality in controls does not exceed 10% and analytical measurements have been performed (+/-20%)
- Conclusions:
- A LC50 of 37.8 mg/L in 96 hours was determined in a test with Fathead Minnow in the presence for benzyldimethylamine (Geiger, 1986).
- Executive summary:
In a 96-h acute toxicity study, Fathead Minnow (Pimephales promelas) were exposed to benzyldimethylamine at nominal concentrations of 14.2 mg/L, 21.8 mg/L, 33.6 mg/L, 51.7 mg/L and 79.5 mg/L under static conditions. The 96-h LC50 was 37.8 mg/L, based on mortality. Affected fish lost schooling behavior, swam near the tank surface, and were overreactive to external stimuli. Equilibrium loss was not observed prior to death. The pH of the stock solution was adjusted to that of lake water with HCl.
Reference
Description of key information
A LC50 of 37.8 mg/L in 96 hours was determined in a test with Fathead Minnow in the presence for benzyldimethylamine (Geiger, 1986). This value is further supported by additional short therm toxicity to fish studies.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 37.8 mg/L
Additional information
Key study:
In a 96-h acute toxicity study, Fathead Minnow (Pimephales promelas) were exposed to benzyldimethylamine at nominal concentrations of 14.2 mg/L, 21.8 mg/L, 33.6 mg/L, 51.7 mg/L and 79.5 mg/L under static conditions. The 96-h LC50 was 37.8 mg/L, based on mortality. Affected fish lost schooling behavior, swam near the tank surface, and were overreactive to external stimuli. Equilibrium loss was not observed prior to death. The pH of the stock solution was adjusted to that of lake water with HCl (Geiger, 1986).
Supporting studies:
- In a supporting study (BASF, 1987) golden orfe were tested in a static freshwater test. In non pH adjusted water a LC0 of 10 mg/L and a LC100 of 46.4 mg/L were measured, whereas in adjusted water also a LC0 of 10 mg/L and a LC100 of > 100 mg/L was noted. In both cases no exact LC50 was derived. This study shows that the toxic effects are mainly attributed to the change of pH. The values with adjusted pH strongly support the findings of the key study.
- In a static freshwater test by Bayer (1979) with Leuciscus idus only a LC0 of 20 mg/L could be detected. No information about pH adjustment was given.
- In a 48 h semistatic freshwater test with Oryzias latipes (MITI, 1992) an LC50 of 59.3 mg/L. No information about pH adjustment was given.
Conclusion:
The LC50 value of 37.8 mg/L determined in the key study is further strengthened by the findings in the supporting studies. Lower values found in the study by BASF (1987) are due to non adjusted pH. With an adjusted pH the study by BASF (1987) is in line with the key study, where also an adjustement of the pH was done.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
